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Slc22a18 Gene Detail
Summary
  • Symbol
    Slc22a18
  • Name
    solute carrier family 22 (organic cation transporter), member 18
  • Synonyms
    BWR1A, BWSCR1A, Impt1, IMPT1, Orctl2, p45-BWR1A, Slc22a1l, TSSC5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336884
    NCBI Gene: 18400
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:143027502-143053071 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.22 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    609 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336884
 protein coding gene Chr7:143027473-143053071 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033273
 protein coding gene Chr7:148758523-148798298 (+)
A/J MGP_AJ_G0033256
 protein coding gene Chr7:144444143-144482035 (+)
AKR/J MGP_AKRJ_G0033187
 protein coding gene Chr7:148494632-148532503 (+)
BALB/cJ MGP_BALBcJ_G0033256
 protein coding gene Chr7:144229223-144267190 (+)
C3H/HeJ MGP_C3HHeJ_G0032972
 protein coding gene Chr7:148258959-148296953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033766
 protein coding gene Chr7:154129642-154169055 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030739
 protein coding gene Chr7:145668691-145701277 (+)
CAST/EiJ MGP_CASTEiJ_G0032294
 protein coding gene Chr7:140586135-140614810 (+)
CBA/J MGP_CBAJ_G0032943
 protein coding gene Chr7:159401145-159427336 (+)
DBA/2J MGP_DBA2J_G0033097
 protein coding gene Chr7:142416490-142455633 (+)
FVB/NJ MGP_FVBNJ_G0033045
 protein coding gene Chr7:142358200-142389198 (+)
LP/J MGP_LPJ_G0033189
 protein coding gene Chr7:150282514-150320248 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033079
 protein coding gene Chr7:159981896-160021873 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033786
 protein coding gene Chr7:147465285-147509134 (+)
PWK/PhJ MGP_PWKPhJ_G0032003
 protein coding gene Chr7:135729872-135768421 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031849
 protein coding gene Chr7:134275255-134314249 (+)
WSB/EiJ MGP_WSBEiJ_G0032406
 protein coding gene Chr7:148478208-148504685 (+)



Homology
more
  • Human Ortholog
    SLC22A18, solute carrier family 22 member 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC22A18, solute carrier family 22 member 18
  • Synonyms
    BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, p45-BWR1A, SLC22A1L, TSSC5
  • Links
    NCBI Gene ID: 5002
    neXtProt AC: NX_Q96BI1
    UniProt: Q96BI1

  • Chr Location
    11p15.4; chr11:2899691-2925246 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SLC22A18 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    27 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show decreased hepatic triglyceride content under refeeding conditions following fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    165
  • cDNA Data
    14
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18400 NCBI Gene Model | MGI Sequence Detail 25570 C57BL/6J ±  kb
    transcript NM_001042760 RefSeq | MGI Sequence Detail 1535 Not Specified  
    polypeptide Q78KK3 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000014986 solute carrier family 22 member 18
      (term hierarchy)
    • InterPro Domains
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG-like
    • GlyGen
      Q78KK3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 14
      cDNA 14
      Primer pair 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1202892, MGI:1332650, MGI:2142225
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 16
      Diseases 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:349247 Yamamoto T, et al., Overexpression of Slc22a18 facilitates fat accumulation in mice. Biochem Biophys Res Commun. 2024 Jun 18;712-713:149922
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory