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Mocs2 Gene Detail
Summary
  • Symbol
    Mocs2
  • Name
    molybdenum cofactor synthesis 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336894
    NCBI Gene: 17434
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:114954707-114965960 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 64.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    493 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336894
 protein coding gene Chr13:114954707-114968811 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020957
 protein coding gene Chr13:117553043-117565024 (+)
A/J MGP_AJ_G0020907
 protein coding gene Chr13:112780898-112794591 (+)
AKR/J MGP_AKRJ_G0020882
 protein coding gene Chr13:116181842-116192392 (+)
BALB/cJ MGP_BALBcJ_G0020907
 protein coding gene Chr13:113503413-113514252 (+)
C3H/HeJ MGP_C3HHeJ_G0020696
 protein coding gene Chr13:116008476-116020103 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021343
 protein coding gene Chr13:120985445-120996132 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018912
 protein coding gene Chr13:108058092-108069441 (+)
CAST/EiJ MGP_CASTEiJ_G0020215
 protein coding gene Chr13:115672543-115686255 (+)
CBA/J MGP_CBAJ_G0020658
 protein coding gene Chr13:125603391-125614208 (+)
DBA/2J MGP_DBA2J_G0020781
 protein coding gene Chr13:112491615-112503510 (+)
FVB/NJ MGP_FVBNJ_G0020765
 protein coding gene Chr13:111145157-111155722 (+)
LP/J MGP_LPJ_G0020857
 protein coding gene Chr13:117549692-117561175 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020793
 protein coding gene Chr13:125887236-125898944 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021379
 protein coding gene Chr13:115667044-115681214 (+)
PWK/PhJ MGP_PWKPhJ_G0019968
 protein coding gene Chr13:111278091-111291748 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019790
 protein coding gene Chr13:112005407-112017497 (+)
WSB/EiJ MGP_WSBEiJ_G0020273
 protein coding gene Chr13:116298864-116314459 (+)



Homology
more
  • Human Ortholog
    MOCS2, molybdenum cofactor synthesis 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOCS2, molybdenum cofactor synthesis 2
  • Synonyms
    MCBPE, MOCO1, MOCODB, MPTS
  • Links
    NCBI Gene ID: 4338
    neXtProt AC: NX_O96007, NX_O96033
    UniProt: O96007, O96033

  • Chr Location
    5q11.2; chr5:53095679-53110063 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mocs2 mouse models; 1 with human MOCS2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show inactivity of all molybdenum-dependent enzymes, slow weight gain, weakness, curly whiskers, hair growth and skin abnormalities, altered levels of purines, uric acid and S-sulfocysteine, bladder and kidney stone formation, increased neuronal apoptosis, and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    30
  • cDNA Data
    86
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17434 NCBI Gene Model | MGI Sequence Detail 11254 C57BL/6J ±  kb
    transcript NM_013826 RefSeq | MGI Sequence Detail 1872 C57BL/6  
    polypeptide Q9Z223 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000029633 bicistronic molybdopterin synthase catalytic subunit/molybdopterin synthase sulfur carrier subunit
      (term hierarchy)
    • EC
      2.8.1.12
    • InterPro Domains
      IPR012675 Beta-grasp domain superfamily
      IPR003448 Molybdopterin biosynthesis MoaE
      IPR036563 Molybdopterin biosynthesis MoaE subunit superfamily
      IPR028888 Molybdopterin synthase catalytic subunit, eukaryotes
      IPR044672 Molybdopterin synthase sulfur carrier subunit
      IPR028887 Molybdopterin synthase sulfur carrier subunit, eukaryote
      IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp
      IPR003749 Sulfur carrier ThiS/MoaD-like
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 86
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145228
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:53881 Stallmeyer B, et al., Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames. Am J Hum Genet. 1999 Mar;64(3):698-705
    • Latest
      J:357548 Karampelias C, et al., Examining the liver-pancreas crosstalk reveals a role for the molybdenum cofactor in beta-cell regeneration. Life Sci Alliance. 2024 Nov;7(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory