Loxl3 MGI Mouse Gene Detail - MGI:1337004

Symbol

Loxl3
Name

lysyl oxidase-like 3
Synonyms

Lor2

Feature Type

protein coding gene
IDs

MGI:1337004
NCBI Gene: 16950
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:83011186-83029547 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.94 cM
Mapping Data

2 experiments

SNPs within 2kb

359 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1337004	protein coding gene	Chr6:83011154-83029547 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030910	protein coding gene	Chr6:84036854-84056245 (+)
A/J	MGP_AJ_G0030879	protein coding gene	Chr6:80822895-80842911 (+)
AKR/J	MGP_AKRJ_G0030807	protein coding gene	Chr6:83153998-83172366 (+)
BALB/cJ	MGP_BALBcJ_G0030889	protein coding gene	Chr6:80837276-80855866 (+)
C3H/HeJ	MGP_C3HHeJ_G0030821	protein coding gene	Chr6:101211290-101229513 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031349	protein coding gene	Chr6:86316328-86335612 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028535	protein coding gene	Chr6:79182979-79201596 (+)
CAST/EiJ	MGP_CASTEiJ_G0029998	protein coding gene	Chr6:83152235-83172459 (+)
CBA/J	MGP_CBAJ_G0030576	protein coding gene	Chr6:89729643-89747885 (+)
DBA/2J	MGP_DBA2J_G0030729	protein coding gene	Chr6:80144276-80162520 (+)
FVB/NJ	MGP_FVBNJ_G0030682	protein coding gene	Chr6:79351079-79370237 (+)
LP/J	MGP_LPJ_G0030808	protein coding gene	Chr6:84029766-84050145 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030718	protein coding gene	Chr6:94032741-94052643 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031373	protein coding gene	Chr6:82966352-82985115 (+)
PWK/PhJ	MGP_PWKPhJ_G0029713	protein coding gene	Chr6:79035008-79054715 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029541	protein coding gene	Chr6:81810562-81831626 (+)
WSB/EiJ	MGP_WSBEiJ_G0030079	protein coding gene	Chr6:83406359-83424702 (+)

Human Ortholog

LOXL3, lysyl oxidase like 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LOXL3, lysyl oxidase like 3
Synonyms

LOXL, MYP28
Links

HGNC:13869

NCBI Gene ID: 84695

neXtProt AC: NX_P58215

UniProt: P58215
Chr Location

2p13.1; chr2:74532258-74555702 (-) GRCh38

MGI Vertebrate Homology

Loxl3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LOXL3
Gene Tree

Loxl3

Diseases

1 with human LOXL3 associations

				Human Disease	Mouse Models
				myopia IDs myopia DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Spontaneous

1
Targeted

6
Genomic Mutations

2 involving Loxl3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lethality shortly after birth, craniofacial and vertebral abnormalities associated with collagen deformities.

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All GO Annotations

31
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

47
cDNA Data

8
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

2
UniProt

3
CCDS

CCDS20266.1

Ensembl

ENSMUSG00000000693 (Evidence)
NCBI Gene

16950

			Length	Strain/Species	Flank
genomic	16950	NCBI Gene Model \| MGI Sequence Detail	18362	C57BL/6J	± kb
transcript	NM_013586	RefSeq \| MGI Sequence Detail	4070	ZRU/MplStud
polypeptide	Q9Z175	UniProt \| EBI \| MGI Sequence Detail	754	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009886 lysyl oxidase homolog 3

(term hierarchy)
EC

1.4.3.-, 1.4.3.13
InterPro Domains

IPR001695 Lysyl oxidase

IPR019828 Lysyl oxidase, conserved site

IPR050912 Lysyl oxidase-like protein

IPR001190 SRCR domain

IPR017448 SRCR-like domain

IPR036772 SRCR-like domain superfamily
GlyGen

Q9Z175 5 sites, 1 N-linked glycan (1 site)

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All nucleic 13

Genomic 3

cDNA 8

Primer pair 2

Microarray probesets 4

Summaries

All 45

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 18
Earliest

J:52798 Jang W, et al., Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13. Genome Res. 1999 Jan;9(1):53-61
Latest

J:337013 Melamed S, et al., Initiation of fibronectin fibrillogenesis is an enzyme-dependent process. Cell Rep. 2023 May 30;42(5):112473

TSS for Loxl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57274	Chr6:83009786-83009801 (+)	-1,392 bp
Tssr57275	Chr6:83011169-83011233 (+)	15 bp
Tssr57276	Chr6:83016257-83016264 (+)	5,075 bp
Tssr57278	Chr6:83028250-83028266 (+)	17,072 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24