Galr2 MGI Mouse Gene Detail - MGI:1337018

Symbol

Galr2
Name

galanin receptor 2
Synonyms

GalR2, mGalR

Feature Type

protein coding gene
IDs

MGI:1337018
NCBI Gene: 14428
Alliance

gene page

Sequence Map

Chr11:116171765-116174764 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 81.10 cM
Mapping Data

3 experiments

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1337018	protein coding gene	Chr11:116170520-116174776 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019422	protein coding gene	Chr11:120384188-120387187 (+)
A/J	MGP_AJ_G0019391	protein coding gene	Chr11:115123675-115126673 (+)
AKR/J	MGP_AKRJ_G0019361	protein coding gene	Chr11:118552265-118555263 (+)
BALB/cJ	MGP_BALBcJ_G0019365	protein coding gene	Chr11:115533030-115536028 (+)
C3H/HeJ	MGP_C3HHeJ_G0019171	protein coding gene	Chr11:118905124-118908122 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019815	protein coding gene	Chr11:124078723-124081722 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017438	protein coding gene	Chr11:112133360-112136348 (+)
CAST/EiJ	MGP_CASTEiJ_G0018726	protein coding gene	Chr11:120267585-120270569 (+)
CBA/J	MGP_CBAJ_G0019143	protein coding gene	Chr11:128969145-128972143 (+)
DBA/2J	MGP_DBA2J_G0019254	protein coding gene	Chr11:114537308-114540306 (+)
FVB/NJ	MGP_FVBNJ_G0019246	protein coding gene	Chr11:114055034-114058031 (+)
LP/J	MGP_LPJ_G0019324	protein coding gene	Chr11:120764708-120767706 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019279	protein coding gene	Chr11:128042602-128045601 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019853	protein coding gene	Chr11:119210861-119213860 (+)
PWK/PhJ	MGP_PWKPhJ_G0018490	protein coding gene	Chr11:115871795-115874800 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018283	protein coding gene	Chr11:118963648-118966635 (+)
WSB/EiJ	MGP_WSBEiJ_G0018778	protein coding gene	Chr11:119178667-119181664 (+)

Human Ortholog

GALR2, galanin receptor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GALR2, galanin receptor 2
Synonyms

GAL2-R, GALNR2, GALR-2
Links

HGNC:4133

NCBI Gene ID: 8811

neXtProt AC: NX_O43603

UniProt: O43603
Chr Location

17q25.1; chr17:76071962-76077537 (+) GRCh38

MGI Vertebrate Homology

Galr2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GALR2
Gene Tree

Galr2

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Phenotype Summary

9 phenotypes from 4 alleles in 5 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

4
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display a reduction in exploratory activity. There is also a modest shift in the distribution of different lymphocyte cell types.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

5
cDNA Data

7
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GALR2

ZFIN galr2b

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS25663.1

Ensembl

ENSMUSG00000020793 (Evidence)
NCBI Gene

14428

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020793	Ensembl Gene Model \| MGI Sequence Detail	3000	C57BL/6J	± kb
transcript	ENSMUST00000055872	Ensembl \| MGI Sequence Detail	1940	Not Applicable
polypeptide	ENSMUSP00000054062	Ensembl \| MGI Sequence Detail	371	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001586 galanin receptor type 2

(term hierarchy)
InterPro Domains

IPR003907 Galanin receptor 2

IPR000405 Galanin receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

O88854 1 site

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All nucleic 7

cDNA 7

Microarray probesets 3

Summaries

All 64

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 25
Earliest

J:51042 Pang L, et al., The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization. J Neurochem. 1998 Dec;71(6):2252-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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