Ier5 MGI Mouse Gene Detail - MGI:1337072 - immediate early response 5

Symbol

Ier5
Name

immediate early response 5

Feature Type

protein coding gene
IDs

MGI:1337072
NCBI Gene: 15939
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:154972113-154975382 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 66.45 cM
Mapping Data

1 experiment

SNPs within 2kb

75 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1337072	protein coding gene	Chr1:154972107-154975382 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016609	protein coding gene	Chr1:159996888-160000163 (-)
A/J	MGP_AJ_G0016590	protein coding gene	Chr1:153576816-153580091 (-)
AKR/J	MGP_AKRJ_G0016556	protein coding gene	Chr1:158298426-158301701 (-)
BALB/cJ	MGP_BALBcJ_G0016551	protein coding gene	Chr1:154088790-154092065 (-)
C3H/HeJ	MGP_C3HHeJ_G0016375	protein coding gene	Chr1:158426246-158429521 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017012	protein coding gene	Chr1:165512540-165515815 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014721	protein coding gene	Chr1:145801327-145804634 (-)
CAST/EiJ	MGP_CASTEiJ_G0015955	protein coding gene	Chr1:157936272-157939545 (-)
CBA/J	MGP_CBAJ_G0016350	protein coding gene	Chr1:171353808-171357083 (-)
DBA/2J	MGP_DBA2J_G0016456	protein coding gene	Chr1:152554047-152557320 (-)
FVB/NJ	MGP_FVBNJ_G0016454	protein coding gene	Chr1:151022670-151025945 (-)
LP/J	MGP_LPJ_G0016527	protein coding gene	Chr1:161147036-161150315 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016479	protein coding gene	Chr1:178934671-178937946 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017048	protein coding gene	Chr1:158103955-158107230 (-)
PWK/PhJ	MGP_PWKPhJ_G0015741	protein coding gene	Chr1:151620285-151623560 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015528	protein coding gene	Chr1:156846668-156849947 (-)
WSB/EiJ	MGP_WSBEiJ_G0016017	protein coding gene	Chr1:158167647-158170923 (-)

Human Ortholog

IER5, immediate early response 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IER5, immediate early response 5
Synonyms

SBBI48
Links

HGNC:5393

NCBI Gene ID: 51278

neXtProt AC: NX_Q5VY09

UniProt: Q5VY09
Chr Location

1q25.3; chr1:181088700-181092900 (+) GRCh38

MGI Vertebrate Homology

Ier5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IER5
Gene Tree

Ier5

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

2
Endonuclease-mediated

2
Genomic Mutations

2 involving Ier5
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

20
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

38
cDNA Data

144
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ier5

ZFIN ier5

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS15382.1

Ensembl

ENSMUSG00000056708 (Evidence)
NCBI Gene

15939

			Length	Strain/Species	Flank
genomic	15939	NCBI Gene Model \| MGI Sequence Detail	3270	C57BL/6J	± kb
transcript	NM_010500	RefSeq \| MGI Sequence Detail	3272	ZRU/MplStud
polypeptide	O89113	UniProt \| EBI \| MGI Sequence Detail	308	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008899 immediate early response gene 5 protein

(term hierarchy)
InterPro Domains

IPR008653 Immediate early response

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All nucleic 147

Genomic 2

cDNA 144

Primer pair 1

Microarray probesets 4

Summaries

All 32

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 6
Earliest

J:53195 Williams M, et al., Ier5, a novel member of the slow-kinetics immediate-early genes. Genomics. 1999 Feb 1;55(3):327-34
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ier5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14339	Chr1:154975376-154975379 (-)	4 bp
Tssr14338	Chr1:154975279-154975290 (-)	97 bp
Tssr14337	Chr1:154975216-154975227 (-)	160 bp
Tssr14336	Chr1:154974478-154974492 (-)	897 bp
Tssr14335	Chr1:154973732-154973748 (-)	1,642 bp
Tssr249	Chr1:154972473-154972494 (-)	2,898 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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