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Wdr1 Gene Detail
Summary
  • Symbol
    Wdr1
  • Name
    WD repeat domain 1
  • Synonyms
    Aip1, D5Wsu185e, rede
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337100
    NCBI Gene: 22388
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:38684149-38720265 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 20.63 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    945 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337100
 protein coding gene Chr5:38684149-38720564 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029513
 protein coding gene Chr5:36943412-36979811 (-)
A/J MGP_AJ_G0029479
 protein coding gene Chr5:35698591-35735029 (-)
AKR/J MGP_AKRJ_G0029429
 protein coding gene Chr5:37038812-37075349 (-)
BALB/cJ MGP_BALBcJ_G0029490
 protein coding gene Chr5:36189429-36226019 (-)
C3H/HeJ MGP_C3HHeJ_G0029213
 protein coding gene Chr5:37033128-37069638 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029944
 protein coding gene Chr5:38889214-38925634 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027182
 protein coding gene Chr5:33369142-33405554 (-)
CAST/EiJ MGP_CASTEiJ_G0028621
 protein coding gene Chr5:36200606-36238476 (-)
CBA/J MGP_CBAJ_G0029180
 protein coding gene Chr5:39809963-39846424 (-)
DBA/2J MGP_DBA2J_G0029327
 protein coding gene Chr5:35830948-35867348 (-)
FVB/NJ MGP_FVBNJ_G0029286
 protein coding gene Chr5:35316253-35354064 (-)
LP/J MGP_LPJ_G0029413
 protein coding gene Chr5:37400670-37437061 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029316
 protein coding gene Chr5:40523879-40563327 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029977
 protein coding gene Chr5:36530061-36567663 (-)
PWK/PhJ MGP_PWKPhJ_G0028345
 protein coding gene Chr5:34990597-35027028 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028179
 protein coding gene Chr5:35973852-36012856 (-)
WSB/EiJ MGP_WSBEiJ_G0028702
 protein coding gene Chr5:36620597-36658391 (-)



Homology
more
  • Human Ortholog
    WDR1, WD repeat domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR1, WD repeat domain 1
  • Synonyms
    AIP1, HEL-S-52, NORI-1, PFITS
  • Links
    NCBI Gene ID: 9948
    neXtProt AC: NX_O75083
    UniProt: O75083

  • Chr Location
    4p16.1; chr4:10068089-10116972 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Severe loss of function at this locus causes embryonic lethality. Mice homozygous for a hypomorphic ENU-induced allele exhibit thrombocytopenia due to impaired megakaryocyte maturation and platelet shedding, and develop autoinflammatory disease associated with defects in neutrophil function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    51
  • cDNA Data
    20
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22388 NCBI Gene Model | MGI Sequence Detail 36117 C57BL/6J ±  kb
    transcript NM_011715 RefSeq | MGI Sequence Detail 2989 ZRU/MplStud  
    polypeptide O88342 UniProt | EBI | MGI Sequence Detail 606 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000017387 WD repeat-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR020472 G-protein beta WD-40 repeat
      IPR011045 Nitrous oxide reductase, N-terminal
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      O88342 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 20
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36476, MGI:107897, MGI:2671645
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 13
      Phenotypes 36
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory