Rev3l MGI Mouse Gene Detail - MGI:1337131 - REV3 like, DNA directed polymerase zeta catalytic subunit

Symbol

Rev3l
Name

REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms

Rev, Sez4

Feature Type

protein coding gene
IDs

MGI:1337131
NCBI Gene: 19714
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:39608114-39751207 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 21.04 cM
Mapping Data

4 experiments

SNPs within 2kb

2861 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1337131	protein coding gene	Chr10:39607557-39751207 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017153	protein coding gene	Chr10:38255434-38401069 (+)
A/J	MGP_AJ_G0017130	protein coding gene	Chr10:37233266-37373085 (+)
AKR/J	MGP_AKRJ_G0017090	protein coding gene	Chr10:37751359-37893735 (+)
BALB/cJ	MGP_BALBcJ_G0017093	protein coding gene	Chr10:37277245-37439980 (+)
C3H/HeJ	MGP_C3HHeJ_G0016913	protein coding gene	Chr10:38078471-38221603 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017551	protein coding gene	Chr10:39424620-39579179 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015248	protein coding gene	Chr10:35216981-35366345 (+)
CAST/EiJ	MGP_CASTEiJ_G0016492	protein coding gene	Chr10:38238556-38391366 (+)
CBA/J	MGP_CBAJ_G0016887	protein coding gene	Chr10:41251091-41402299 (+)
DBA/2J	MGP_DBA2J_G0016992	protein coding gene	Chr10:36753742-36898022 (+)
FVB/NJ	MGP_FVBNJ_G0016987	protein coding gene	Chr10:36258459-36399532 (+)
LP/J	MGP_LPJ_G0017069	protein coding gene	Chr10:38227194-38374280 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017017	protein coding gene	Chr10:42090955-42255812 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017588	protein coding gene	Chr10:37740237-37885153 (+)
PWK/PhJ	MGP_PWKPhJ_G0016273	protein coding gene	Chr10:36598112-36739541 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016057	protein coding gene	Chr10:37538402-37682915 (+)
WSB/EiJ	MGP_WSBEiJ_G0016555	protein coding gene	Chr10:38016922-38164019 (+)

Human Ortholog

REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REV3L, REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms

POLZ, REV3
Links

HGNC:9968

NCBI Gene ID: 5980

neXtProt AC: NX_O60673

UniProt: O60673
Chr Location

6q21; chr6:111299028-111483715 (-) GRCh38

MGI Vertebrate Homology

Rev3l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: REV3L
Gene Tree

Rev3l

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Phenotype Summary

35 phenotypes from 10 alleles in 7 genetic backgrounds
11 phenotypes from multigenic genotypes
1 images
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Radiation induced

1
Targeted

15
Genomic Mutations

2 involving Rev3l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

120 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice exhibit complete embryonic lethality and abnormal embryonic tissue morphology with widespread degeneration and cell death. Mice carrying the amino acid substitution of phenylalanine for leucine at position 2610 display alterations in somatic hypermutation frequency and specificity.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

935
Tissues

160
cDNA Data

117
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rev3l

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All Sequences

61
RefSeq

13
UniProt

7
CCDS

CCDS23790.1

Ensembl

ENSMUSG00000019841 (Evidence)
NCBI Gene

19714

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019841	Ensembl Gene Model \| MGI Sequence Detail	143094	C57BL/6J	± kb
transcript	ENSMUST00000019986	Ensembl \| MGI Sequence Detail	10713	Not Applicable
polypeptide	ENSMUSP00000019986	Ensembl \| MGI Sequence Detail	3122	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013900 DNA polymerase zeta catalytic subunit

(term hierarchy)
PDB

4FJO
EC

2.7.7.7
InterPro Domains

IPR025687 C4-type zinc-finger of DNA polymerase delta

IPR006172 DNA-directed DNA polymerase, family B

IPR017964 DNA-directed DNA polymerase, family B, conserved site

IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain

IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain

IPR042087 DNA polymerase family B, thumb domain

IPR023211 DNA polymerase, palm domain superfamily

IPR030559 DNA polymerase zeta catalytic subunit

IPR043502 DNA/RNA polymerase superfamily

IPR032757 Domain of unknown function DUF4683

IPR042794 Neurite extension and migration factor

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

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All nucleic 119

Genomic 1

cDNA 117

Primer pair 1

Microarray probesets 5

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MGD-MRK-39490, MGI:109491

Summaries

All 71

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rev3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93000	Chr10:39608095-39608136 (+)	2 bp
Tssr93001	Chr10:39608157-39608172 (+)	51 bp
Tssr93002	Chr10:39608190-39608199 (+)	81 bp
Tssr93003	Chr10:39608379-39608446 (+)	299 bp
Tssr93004	Chr10:39612845-39612853 (+)	4,735 bp
Tssr93005	Chr10:39653583-39653586 (+)	45,471 bp
Tssr93006	Chr10:39670918-39670928 (+)	62,809 bp
Tssr93007	Chr10:39677355-39677358 (+)	69,243 bp
Tssr93008	Chr10:39698562-39698577 (+)	90,456 bp
Tssr93009	Chr10:39699929-39699946 (+)	91,824 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24