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Bcl10 Gene Detail
Summary
  • Symbol
    Bcl10
  • Name
    B cell leukemia/lymphoma 10
  • Synonyms
    BCL-10, cE10, mE10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337994
    NCBI Gene: 12042
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:145630017-145640121 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 71.03 cM, cytoband H3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337994
 protein coding gene Chr3:145628559-145640121 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027963
 protein coding gene Chr3:149377557-149391260 (+)
A/J MGP_AJ_G0027922
 protein coding gene Chr3:144056513-144068053 (+)
AKR/J MGP_AKRJ_G0027888
 protein coding gene Chr3:147883089-147894641 (+)
BALB/cJ MGP_BALBcJ_G0027934
 protein coding gene Chr3:143871979-143883515 (+)
C3H/HeJ MGP_C3HHeJ_G0027664
 protein coding gene Chr3:148252743-148265437 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028377
 protein coding gene Chr3:154444489-154456033 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024872
 protein coding gene Chr3:14785133-139136307 (+)
CAST/EiJ MGP_CASTEiJ_G0027117
 protein coding gene Chr3:148212852-148224624 (+)
CBA/J MGP_CBAJ_G0027639
 protein coding gene Chr3:159869993-159881520 (+)
DBA/2J MGP_DBA2J_G0027779
 protein coding gene Chr3:143196857-143208396 (+)
FVB/NJ MGP_FVBNJ_G0027746
 protein coding gene Chr3:140607600-140619128 (+)
LP/J MGP_LPJ_G0027890
 protein coding gene Chr3:150772968-150784553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027779
 protein coding gene Chr3:168175653-168188060 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028436
 protein coding gene Chr3:147479584-147491068 (+)
PWK/PhJ MGP_PWKPhJ_G0026840
 protein coding gene Chr3:143044153-143056481 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026668
 protein coding gene Chr3:145639145-145650518 (+)
WSB/EiJ MGP_WSBEiJ_G0027197
 protein coding gene Chr3:148435307-148448125 (+)



Homology
more
  • Human Ortholog
    BCL10, BCL10 immune signaling adaptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL10, BCL10 immune signaling adaptor
  • Synonyms
    CARMEN, c-E10, CIPER, CLAP, IMD37, mE10
  • Links
    NCBI Gene ID: 8915
    neXtProt AC: NX_O95999
    UniProt: O95999

  • Chr Location
    1p22.3; chr1:85265776-85276632 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human BCL10 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About one-third of homozygous null embryos die exhibiting exencephaly. Surviving mutants display immunological defects including severe immunodeficiency, abnormal B cell development and function, and impaired humoral response to bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    49
  • cDNA Data
    110
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12042 NCBI Gene Model | MGI Sequence Detail 10105 C57BL/6J ±  kb
    transcript NM_009740 RefSeq | MGI Sequence Detail 1959 C57BL/6  
    polypeptide Q9Z0H7 UniProt | EBI | MGI Sequence Detail 233 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 110

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2139636, MGI:2140085
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 23
      Phenotypes 48
    • Earliest
      J:52071 Willis TG, et al., Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell. 1999 Jan 8;96(1):35-45
    • Latest
      J:324853 Sugisawa E, et al., Nociceptor-derived Reg3gamma prevents endotoxic death by targeting kynurenine pathway in microglia. Cell Rep. 2022 Mar 8;38(10):110462
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory