Klhl22 MGI Mouse Gene Detail - MGI:1337995

Symbol

Klhl22
Name

kelch-like 22
Synonyms

2610318I18Rik, Kelchl

Feature Type

protein coding gene
IDs

MGI:1337995
NCBI Gene: 224023
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:17577485-17611246 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 11.01 cM
Mapping Data

4 experiments

SNPs within 2kb

57 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1337995	protein coding gene	Chr16:17577482-17611246 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022590	protein coding gene	Chr16:14940995-14974531 (+)
A/J	MGP_AJ_G0022551	protein coding gene	Chr16:14193837-14228680 (+)
AKR/J	MGP_AKRJ_G0022528	protein coding gene	Chr16:14747807-14783333 (+)
BALB/cJ	MGP_BALBcJ_G0022554	protein coding gene	Chr16:14346731-14380404 (+)
C3H/HeJ	MGP_C3HHeJ_G0022321	protein coding gene	Chr16:14893436-14928464 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023005	protein coding gene	Chr16:15169890-15204815 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020525	protein coding gene	Chr16:14250616-14285628 (+)
CAST/EiJ	MGP_CASTEiJ_G0021849	protein coding gene	Chr16:14815978-14852155 (+)
CBA/J	MGP_CBAJ_G0022292	protein coding gene	Chr16:15847885-15883620 (+)
DBA/2J	MGP_DBA2J_G0022422	protein coding gene	Chr16:14107293-14140893 (+)
FVB/NJ	MGP_FVBNJ_G0022398	protein coding gene	Chr16:14149966-14188260 (+)
LP/J	MGP_LPJ_G0022489	protein coding gene	Chr16:14707674-14744239 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022419	protein coding gene	Chr16:15533652-15570476 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023016	protein coding gene	Chr16:14694662-14728282 (+)
PWK/PhJ	MGP_PWKPhJ_G0021592	protein coding gene	Chr16:14367016-14400915 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021420	protein coding gene	Chr16:14664056-14700455 (+)
WSB/EiJ	MGP_WSBEiJ_G0021896	protein coding gene	Chr16:14679509-14713938 (+)

Human Ortholog

KLHL22, kelch like family member 22

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL22, kelch like family member 22
Synonyms

KELCHL
Links

HGNC:25888

NCBI Gene ID: 84861

neXtProt AC: NX_Q53GT1

UniProt: Q53GT1
Chr Location

22q11.21; chr22:20441519-20495844 (-) GRCh38

MGI Vertebrate Homology

Klhl22 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHL22
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Klhl22

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

8
Targeted

1
Genomic Mutations

1 involving Klhl22
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased growth of implanted tumor cells with reduced survival and Cd4+ and CD8+ T cells expressing IFNgamma, TNF, and granzyme B.

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All GO Annotations

58
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

95
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl22

ZFIN klhl22

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All Sequences

87
RefSeq

16
UniProt

6
CCDS

CCDS49783.1

Ensembl

ENSMUSG00000022750 (Evidence)
NCBI Gene

224023

			Length	Strain/Species	Flank
genomic	224023	NCBI Gene Model \| MGI Sequence Detail	33762	C57BL/6J	± kb
transcript	NM_001379026	RefSeq \| MGI Sequence Detail	5687	ZRU/MplStud
polypeptide	Q99JN2	UniProt \| EBI \| MGI Sequence Detail	634	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009384 kelch-like protein 22

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR030575 Kelch-like protein 22, BACK domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 101

Genomic 5

cDNA 96

Microarray probesets 3

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MGI:1919759

Summaries

All 43

Developmental Gene Expression 1

Diseases 1

Gene Ontology 5

Phenotypes 13
Earliest

J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Klhl22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137329	Chr16:17577028-17577035 (+)	-453 bp
Tssr137330	Chr16:17577442-17577451 (+)	-38 bp
Tssr137331	Chr16:17577465-17577474 (+)	-15 bp
Tssr137332	Chr16:17577494-17577547 (+)	36 bp
Tssr137333	Chr16:17577551-17577563 (+)	72 bp
Tssr137334	Chr16:17581764-17581767 (+)	4,281 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24