About   Help   FAQ
Cbfa2t3 Gene Detail
Summary
  • Symbol
    Cbfa2t3
  • Name
    CBFA2/RUNX1 translocation partner 3
  • Synonyms
    A630044F12Rik, Eto2, ETO-2, MTGR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338013
    NCBI Gene: 12398
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123351880-123425848 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.93 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1819 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338013
 protein coding gene Chr8:123351875-123426069 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034236
 protein coding gene Chr8:126194038-126269610 (-)
A/J MGP_AJ_G0034216
 protein coding gene Chr8:120958414-121030797 (-)
AKR/J MGP_AKRJ_G0034143
 protein coding gene Chr8:124485036-124560483 (-)
BALB/cJ MGP_BALBcJ_G0034210
 protein coding gene Chr8:121158829-121229885 (-)
C3H/HeJ MGP_C3HHeJ_G0033920
 protein coding gene Chr8:125187603-125263184 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034729
 protein coding gene Chr8:130399885-130500643 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031671
 protein coding gene Chr8:113790838-113860423 (-)
CAST/EiJ MGP_CASTEiJ_G0033248
 protein coding gene Chr8:125267945-125345347 (-)
CBA/J MGP_CBAJ_G0033893
 protein coding gene Chr8:135194072-135283087 (-)
DBA/2J MGP_DBA2J_G0034050
 protein coding gene Chr8:120147779-120220302 (-)
FVB/NJ MGP_FVBNJ_G0033993
 protein coding gene Chr8:119295437-119370197 (-)
LP/J MGP_LPJ_G0034139
 protein coding gene Chr8:126316020-126393766 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034040
 protein coding gene Chr8:137354219-137430053 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034748
 protein coding gene Chr8:124668629-124744702 (-)
PWK/PhJ MGP_PWKPhJ_G0032949
 protein coding gene Chr8:119970501-120040524 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032789
 protein coding gene Chr8:123396994-123470171 (-)
WSB/EiJ MGP_WSBEiJ_G0033364
 protein coding gene Chr8:125423530-125494563 (-)



Homology
more
  • Human Ortholog
    CBFA2T3, CBFA2/RUNX1 partner transcriptional co-repressor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBFA2T3, CBFA2/RUNX1 partner transcriptional co-repressor 3
  • Synonyms
    ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4
  • Links
    NCBI Gene ID: 863
    neXtProt AC: NX_O75081
    UniProt: O75081

  • Chr Location
    16q24.3; chr16:88874858-88977207 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that are homozygote null for this gene display skewing of the early myeloid progenitor cells toward the granulocytic/macrophage lineage while reducing the numbers of megakaryocyte-erythroid progenitor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    75
  • cDNA Data
    13
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006362 Ensembl Gene Model | MGI Sequence Detail 73969 C57BL/6J ±  kb
    transcript ENSMUST00000127984 Ensembl | MGI Sequence Detail 7645 Not Applicable  
    polypeptide ENSMUSP00000118997 Ensembl | MGI Sequence Detail 620 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 1
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2142566, MGI:2142781, MGI:2445014
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:50334 Calabi F, et al., CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Genomics. 1998 Sep 15;52(3):332-41
    • Latest
      J:349160 Lamacova L, et al., CPEB3 Maintains Developmental Competence of the Oocyte. Cells. 2024 May 16;13(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory