Bex3 MGI Mouse Gene Detail - MGI:1338016 - brain expressed X-linked 3

Symbol

Bex3
Name

brain expressed X-linked 3
Synonyms

DXWsu67e, Gcap27, Nade, Ngfrap1, p75NTR-associated Cell Death Executor

Feature Type

protein coding gene
IDs

MGI:1338016
NCBI Gene: 12070
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

ChrX:135171002-135172727 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 57.64 cM
Mapping Data

6 experiments

SNPs within 2kb

92 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338016	protein coding gene	ChrX:135171002-135172727 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036098	protein coding gene	ChrX:133641749-133643272 (+)
A/J	MGP_AJ_G0036079	protein coding gene	ChrX:133044145-133044802 (+)
AKR/J	MGP_AKRJ_G0036005	protein coding gene	ChrX:137308347-137309793 (+)
BALB/cJ	MGP_BALBcJ_G0036067	protein coding gene	ChrX:131426185-131427240 (+)
C3H/HeJ	MGP_C3HHeJ_G0035778	protein coding gene	ChrX:133638464-133639516 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036591	protein coding gene	ChrX:137484935-137486103 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033422	protein coding gene	ChrX:125033717-125035354 (+)
CAST/EiJ	MGP_CASTEiJ_G0035067	protein coding gene	ChrX:114557642-114558311 (+)
CBA/J	MGP_CBAJ_G0035753	protein coding gene	ChrX:141705655-141706707 (+)
DBA/2J	MGP_DBA2J_G0035909	protein coding gene	ChrX:132375346-132376862 (+)
FVB/NJ	MGP_FVBNJ_G0035844	protein coding gene	ChrX:131558571-131559228 (+)
LP/J	MGP_LPJ_G0036004	protein coding gene	ChrX:134563236-134565351 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035879	protein coding gene	ChrX:149092752-149094275 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036629	protein coding gene	ChrX:132992111-132993246 (+)
PWK/PhJ	MGP_PWKPhJ_G0034759	protein coding gene	ChrX:111465397-111466054 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034588	protein coding gene	ChrX:115193828-115194497 (+)
WSB/EiJ	MGP_WSBEiJ_G0035200	protein coding gene	ChrX:131335361-131336018 (+)

Human Ortholog

BEX3, brain expressed X-linked 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BEX3, brain expressed X-linked 3
Synonyms

Bex, DXS6984E, Hero20, HGR74, NADE, NGFRAP1
Links

HGNC:13388

NCBI Gene ID: 27018

neXtProt AC: NX_Q00994

UniProt: Q00994
Chr Location

Xq22.2; chrX:103376323-103378164 (+) GRCh38

MGI Vertebrate Homology

Bex3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BEX3
Protein SuperFamily

BEX
Gene Tree

Bex3

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Phenotype Summary

28 phenotypes from 3 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

6
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit enlarged frontal bone, dilated brain ventricle, increased stereotypic behavior, increased prepulse inhibition, decreased density in motor, cingulate and sensory cortices, and caudate-putamen, decreased total spontaneous activity frequency, and strongly reduced inhibitory postsynaptic current frequency.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

52
cDNA Data

170
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

56
RefSeq

6
UniProt

1
CCDS

CCDS30419.1, CCDS53194.1

Ensembl

ENSMUSG00000046432 (Evidence)
NCBI Gene

12070

			Length	Strain/Species	Flank
genomic	12070	NCBI Gene Model \| MGI Sequence Detail	1726	C57BL/6J	± kb
transcript	NM_009750	RefSeq \| MGI Sequence Detail	939	ZRU/MplStud
polypeptide	Q9WTZ9	UniProt \| EBI \| MGI Sequence Detail	124	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011195 protein BEX3

(term hierarchy)
InterPro Domains

IPR007623 Brain-expressed X-linked protein

IPR021156 Transcription elongation factor A-like/Brain expressed X-linked

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All nucleic 176

cDNA 170

Primer pair 5

Other 1

Microarray probesets 1

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MGD-MRK-18678, MGD-MRK-33932, MGI:101854, MGI:106240, MGI:2147950

Summaries

All 50

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 11
Earliest

J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bex3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162038	ChrX:135171007-135171018 (+)	11 bp
Tssr162039	ChrX:135171027-135171032 (+)	28 bp
Tssr162040	ChrX:135171051-135171101 (+)	74 bp
Tssr162041	ChrX:135172108-135172143 (+)	1,124 bp
Tssr162042	ChrX:135172198-135172216 (+)	1,205 bp
Tssr162043	ChrX:135172417-135172436 (+)	1,425 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24