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Bex2 Gene Detail
Summary
  • Symbol
    Bex2
  • Name
    brain expressed X-linked 2
  • Synonyms
    Bex1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338017
    NCBI Gene: 12069
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:134967314-134968985 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 57.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338017
 protein coding gene ChrX:134967313-134968985 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036092
 protein coding gene ChrX:133422172-133423844 (-)
A/J MGP_AJ_G0036073
 protein coding gene ChrX:132826243-132827964 (-)
AKR/J MGP_AKRJ_G0035999
 protein coding gene ChrX:137090882-137092554 (-)
BALB/cJ MGP_BALBcJ_G0036061
 protein coding gene ChrX:131214504-131216176 (-)
C3H/HeJ MGP_C3HHeJ_G0035771
 protein coding gene ChrX:133414638-133416500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036584
 protein coding gene ChrX:137259102-137260698 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033414
 protein coding gene ChrX:124823584-124824689 (-)
CAST/EiJ MGP_CASTEiJ_G0035060
 protein coding gene ChrX:114338983-114340632 (-)
CBA/J MGP_CBAJ_G0035747
 protein coding gene ChrX:141476418-141481687 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0035838
 protein coding gene ChrX:131337687-131339617 (-)
LP/J MGP_LPJ_G0035996
 protein coding gene ChrX:134351359-134353031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035872
 protein coding gene ChrX:148868001-148869145 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036621
 protein coding gene ChrX:132777000-132778880 (-)
PWK/PhJ MGP_PWKPhJ_G0034751
 protein coding gene ChrX:111252216-111254270 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034582
 protein coding gene ChrX:114989367-114991926 (-)
WSB/EiJ MGP_WSBEiJ_G0035193
 protein coding gene ChrX:131114650-131116322 (-)



Homology
more
  • Human Ortholog
    BEX1, brain expressed X-linked 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BEX1, brain expressed X-linked 1
  • Synonyms
    BEX2, HBEX2, HGR74-h
  • Links
    NCBI Gene ID: 55859
    neXtProt AC: NX_Q9HBH7
    UniProt: Q9HBH7

  • Chr Location
    Xq21-q23
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous or hemizygous for a knock-out allele are viable and fertile and show no obvious phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1056
  • Tissues
    84
  • cDNA Data
    47
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12069 NCBI Gene Model | MGI Sequence Detail 1672 C57BL/6J ±  kb
    transcript NM_009749 RefSeq | MGI Sequence Detail 902 C57BL/6  
    polypeptide Q9WTZ8 UniProt | EBI | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007623 Brain-expressed X-linked protein
      IPR021156 Transcription elongation factor A-like/Brain expressed X-linked
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 47
      Primer pair 5
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147946
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:50125 Faria TN, et al., Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest. Mol Cell Endocrinol. 1998 Aug 25;143(1-2):155-66
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory