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Opn3 Gene Detail
Summary
  • Symbol
    Opn3
  • Name
    opsin 3
  • Synonyms
    Ecpn, encephalopsin, ERO, panopsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338022
    NCBI Gene: 13603
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:175489993-175520198 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 81.66 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    939 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338022
 protein coding gene Chr1:175489987-175520342 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016838
 protein coding gene Chr1:181763865-181794280 (-)
A/J MGP_AJ_G0016817
 protein coding gene Chr1:174440059-174470411 (-)
AKR/J MGP_AKRJ_G0016783
 protein coding gene Chr1:179652689-179683057 (-)
BALB/cJ MGP_BALBcJ_G0016775
 protein coding gene Chr1:174973500-175003866 (-)
C3H/HeJ MGP_C3HHeJ_G0016600
 protein coding gene Chr1:180261662-180292031 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017240
 protein coding gene Chr1:187764068-187794434 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014945
 protein coding gene Chr1:165753747-165784835 (-)
CAST/EiJ MGP_CASTEiJ_G0016181
 protein coding gene Chr1:179629074-179661788 (-)
CBA/J MGP_CBAJ_G0016574
 protein coding gene Chr1:194618121-194648468 (-)
DBA/2J MGP_DBA2J_G0016679
 protein coding gene Chr1:173293517-173323990 (-)
FVB/NJ MGP_FVBNJ_G0016676
 protein coding gene Chr1:171418850-171449239 (-)
LP/J MGP_LPJ_G0016755
 protein coding gene Chr1:182957453-182988296 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016708
 protein coding gene Chr1:201859090-201890624 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017275
 protein coding gene Chr1:179425669-179457534 (-)
PWK/PhJ MGP_PWKPhJ_G0015968
 protein coding gene Chr1:172382989-172413612 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015745
 protein coding gene Chr1:178461304-178493580 (-)
WSB/EiJ MGP_WSBEiJ_G0016243
 protein coding gene Chr1:179622874-179653253 (-)



Homology
more
  • Human Ortholog
    OPN3, opsin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPN3, opsin 3
  • Synonyms
    ECPN, PPP1R116
  • Links
    NCBI Gene ID: 23596
    neXtProt AC: NX_Q9H1Y3
    UniProt: Q9H1Y3

  • Chr Location
    1q43; chr1:241590102-241677376 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal photoentrainment but impaired adaptive thermoregulation. Mice homozygous for a conditional allele activated in adipocytes exhibit blue-light sensitive impairment in adaptive thermoregulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    8
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13603 NCBI Gene Model | MGI Sequence Detail 30206 C57BL/6J ±  kb
    transcript NM_010098 RefSeq | MGI Sequence Detail 1763 C57BL/6  
    polypeptide Q9WUK7 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 10
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:54924 Blackshaw S, et al., Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. J Neurosci. 1999 May 15;19(10):3681-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory