Capn7 MGI Mouse Gene Detail - MGI:1338030

Symbol

Capn7
Name

calpain 7
Synonyms

PalBH

Feature Type

protein coding gene
IDs

MGI:1338030
NCBI Gene: 12339
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:31058595-31093943 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.10 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

897 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338030	protein coding gene	Chr14:31058582-31093944 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021127	protein coding gene	Chr14:24516022-24552010 (+)
A/J	MGP_AJ_G0021075	protein coding gene	Chr14:23590572-23626522 (+)
AKR/J	MGP_AKRJ_G0021052	protein coding gene	Chr14:24715655-24750925 (+)
BALB/cJ	MGP_BALBcJ_G0021079	protein coding gene	Chr14:23716147-23752014 (+)
C3H/HeJ	MGP_C3HHeJ_G0020862	protein coding gene	Chr14:24585049-24621404 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021511	protein coding gene	Chr14:25481269-25518231 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019074	protein coding gene	Chr14:23661497-23695599 (+)
CAST/EiJ	MGP_CASTEiJ_G0020387	protein coding gene	Chr14:24352897-24391574 (+)
CBA/J	MGP_CBAJ_G0020829	protein coding gene	Chr14:26452742-26491897 (+)
DBA/2J	MGP_DBA2J_G0020951	protein coding gene	Chr14:23620724-23656884 (+)
FVB/NJ	MGP_FVBNJ_G0020935	protein coding gene	Chr14:23582533-23618508 (+)
LP/J	MGP_LPJ_G0021020	protein coding gene	Chr14:24842882-24877853 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020961	protein coding gene	Chr14:25719130-25756648 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021544	protein coding gene	Chr14:24475595-24512734 (+)
PWK/PhJ	MGP_PWKPhJ_G0020135	protein coding gene	Chr14:23080874-23117114 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019959	protein coding gene	Chr14:24082622-24118290 (+)
WSB/EiJ	MGP_WSBEiJ_G0020442	protein coding gene	Chr14:24540051-24576118 (+)

Human Ortholog

CAPN7, calpain 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAPN7, calpain 7
Synonyms

CALPAIN7, PALBH
Links

HGNC:1484

NCBI Gene ID: 23473

neXtProt AC: NX_Q9Y6W3

UniProt: Q9Y6W3
Chr Location

3p25.1; chr3:15206152-15252916 (+) GRCh38

MGI Vertebrate Homology

Capn7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CAPN7
Gene Tree

Capn7

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene frequently die before weaning. Survivors display reduced body weight.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

871
Tissues

110
cDNA Data

85
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CAPN7

Xenbase capn7

ZFIN capn7

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All Sequences

67
RefSeq

22
UniProt

2
CCDS

CCDS26911.1

Ensembl

ENSMUSG00000021893 (Evidence)
NCBI Gene

12339

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021893	Ensembl Gene Model \| MGI Sequence Detail	35349	C57BL/6J	± kb
transcript	ENSMUST00000022451	Ensembl \| MGI Sequence Detail	3648	Not Applicable
polypeptide	ENSMUSP00000022451	Ensembl \| MGI Sequence Detail	813	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005019 calpain-7

(term hierarchy)
EC

3.4.22.-
InterPro Domains

IPR036213 Calpain large subunit, domain III superfamily

IPR007330 MIT domain

IPR036181 MIT domain superfamily

IPR051297 PalB/RIM13 Calpain-like Protease

IPR038765 Papain-like cysteine peptidase superfamily

IPR001300 Peptidase C2, calpain, catalytic domain

IPR022683 Peptidase C2, calpain, domain III

IPR022684 Peptidase C2, calpain family

IPR022682 Peptidase C2, calpain, large subunit, domain III

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All nucleic 86

cDNA 85

Primer pair 1

Microarray probesets 5

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MGI:2145742

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 6
Earliest

J:53883 Franz T, et al., Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. Mamm Genome. 1999 Mar;10(3):318-21
Latest

J:320221 Yan Q, et al., Calpain7 impairs embryo implantation by downregulating beta3-integrin expression via degradation of HOXA10. Cell Death Dis. 2018 Feb 19;9(3):291

TSS for Capn7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124939	Chr14:31058590-31058613 (+)	7 bp
Tssr124940	Chr14:31058615-31058676 (+)	51 bp
Tssr124941	Chr14:31058752-31058763 (+)	163 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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