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Phf2 Gene Detail
Summary
  • Symbol
    Phf2
  • Name
    PHD finger protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338034
    NCBI Gene: 18676
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:48955226-49024361 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 24.96 cM, cytoband A3-A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338034
 protein coding gene Chr13:48955226-49024595 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020527
 protein coding gene Chr13:47738858-47796649 (-)
A/J MGP_AJ_G0020481
 protein coding gene Chr13:46049239-46119444 (-)
AKR/J MGP_AKRJ_G0020458
 protein coding gene Chr13:47340638-47414316 (-)
BALB/cJ MGP_BALBcJ_G0020477
 protein coding gene Chr13:46265483-46335162 (-)
C3H/HeJ MGP_C3HHeJ_G0020276
 protein coding gene Chr13:47168774-47242485 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020910
 protein coding gene Chr13:49179729-49253484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018495
 protein coding gene Chr13:44043145-44110771 (-)
CAST/EiJ MGP_CASTEiJ_G0019791
 protein coding gene Chr13:47169789-47249045 (-)
CBA/J MGP_CBAJ_G0020237
 protein coding gene Chr13:51217615-51298670 (-)
DBA/2J MGP_DBA2J_G0020359
 protein coding gene Chr13:45577688-45647273 (-)
FVB/NJ MGP_FVBNJ_G0020338
 protein coding gene Chr13:45090218-45125976 (-)
LP/J MGP_LPJ_G0020434
 protein coding gene Chr13:47965317-48035247 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020367
 protein coding gene Chr13:50956967-51030231 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020953
 protein coding gene Chr13:47045575-47120650 (-)
PWK/PhJ MGP_PWKPhJ_G0019547
 protein coding gene Chr13:45743129-45814207 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019375
 protein coding gene Chr13:45751665-45792297 (-)
WSB/EiJ MGP_WSBEiJ_G0019853
 protein coding gene Chr13:47360101-47431151 (-)



Homology
more
  • Human Ortholog
    PHF2, PHD finger protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHF2, PHD finger protein 2
  • Synonyms
    CENP-35, GRC5, JHDM1E, KDM7C
  • Links
    NCBI Gene ID: 5253
    neXtProt AC: NX_O75151
    UniProt: O75151

  • Chr Location
    9q22.31; chr9:93576584-93679587 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased body weight, decreased adipocity and impaired adipogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    149
  • cDNA Data
    10
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18676 NCBI Gene Model | MGI Sequence Detail 69136 C57BL/6J ±  kb
    transcript NM_011078 RefSeq | MGI Sequence Detail 5260 ZRU/MplStud  
    polypeptide Q9WTU0 UniProt | EBI | MGI Sequence Detail 1096 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:351081 Fukushima T, et al., PHF2 regulates sarcomeric gene transcription in myogenesis. PLoS One. 2024;19(5):e0301690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory