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Itgb8 Gene Detail
Summary
  • Symbol
    Itgb8
  • Name
    integrin beta 8
  • Synonyms
    4832412O06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338035
    NCBI Gene: 320910
  • Alliance
    gene page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:119121757-119202537 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 63.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338035
 protein coding gene Chr12:119121757-119202891 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020190
 protein coding gene Chr12:122163788-122251302 (-)
A/J MGP_AJ_G0020146
 protein coding gene Chr12:117649192-117730547 (-)
AKR/J MGP_AKRJ_G0020121
 protein coding gene Chr12:121225390-121311788 (-)
BALB/cJ MGP_BALBcJ_G0020129
 protein coding gene Chr12:118076420-118166540 (-)
C3H/HeJ MGP_C3HHeJ_G0019933
 protein coding gene Chr12:121526205-121620979 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020576
 protein coding gene Chr12:125962164-126047612 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018188
 protein coding gene Chr12:113990867-114074902 (-)
CAST/EiJ MGP_CASTEiJ_G0019473
 protein coding gene Chr12:115382080-115466009 (-)
CBA/J MGP_CBAJ_G0019900
 protein coding gene Chr12:130936755-131020378 (-)
DBA/2J MGP_DBA2J_G0020017
 protein coding gene Chr12:117038798-117137864 (-)
FVB/NJ MGP_FVBNJ_G0020002
 protein coding gene Chr12:115696141-115777292 (-)
LP/J MGP_LPJ_G0020091
 protein coding gene Chr12:122170673-122256652 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020038
 protein coding gene Chr12:134182816-134274964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020605
 protein coding gene Chr12:120412288-120494875 (-)
PWK/PhJ MGP_PWKPhJ_G0019235
 protein coding gene Chr12:111803934-111886076 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019040
 protein coding gene Chr12:113351558-113435382 (-)
WSB/EiJ MGP_WSBEiJ_G0019531
 protein coding gene Chr12:121373715-121458525 (-)



Homology
more
  • Human Ortholog
    ITGB8, integrin subunit beta 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB8, integrin subunit beta 8
  • Links
    NCBI Gene ID: 3696
    neXtProt AC: NX_P26012
    UniProt: P26012

  • Chr Location
    7p21.1; chr7:20329766-20415754 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 3 alleles in 5 genetic backgrounds
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene either die before E11.5 as a result of circulatory abnormalities in the placenta or die within the first for days after birth and display intracerebral hemorrhaging.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    964
  • Tissues
    74
  • cDNA Data
    48
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025321 Ensembl Gene Model | MGI Sequence Detail 80781 C57BL/6J ±  kb
    transcript ENSMUST00000026360 Ensembl | MGI Sequence Detail 8403 Not Applicable  
    polypeptide ENSMUSP00000026360 Ensembl | MGI Sequence Detail 767 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 48
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2445021
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 19
      Diseases 4
      Gene Ontology 12
      Phenotypes 111
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:352714 Yang J, et al., ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death. J Med Genet. 2024 Jul 19;61(8):750-758
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory