Gnb1l MGI Mouse Gene Detail - MGI:1338057 - guanine nucleotide binding protein (G protein), beta polypeptide 1-like

Symbol

Gnb1l
Name

guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Synonyms

ESTM55, Me49f07, Wdr14, Wdvcf

Feature Type

protein coding gene
IDs

MGI:1338057
NCBI Gene: 13972
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:18317463-18385429 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 11.46 cM
Mapping Data

5 experiments

SNPs within 2kb

127 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338057	protein coding gene	Chr16:18316029-18385430 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022612	protein coding gene	Chr16:15729222-15806674 (+)
A/J	MGP_AJ_G0022573	protein coding gene	Chr16:14947828-15017309 (+)
AKR/J	MGP_AKRJ_G0022550	protein coding gene	Chr16:15540780-15613223 (+)
BALB/cJ	MGP_BALBcJ_G0022578	protein coding gene	Chr16:15098778-15167661 (+)
C3H/HeJ	MGP_C3HHeJ_G0022345	protein coding gene	Chr16:15697418-15768889 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023027	protein coding gene	Chr16:16016345-16089053 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020547	protein coding gene	Chr16:14985681-15053913 (+)
CAST/EiJ	MGP_CASTEiJ_G0021872	protein coding gene	Chr16:15600615-15679472 (+)
CBA/J	MGP_CBAJ_G0022314	protein coding gene	Chr16:16727421-16810120 (+)
DBA/2J	MGP_DBA2J_G0022446	protein coding gene	Chr16:14864179-14931702 (+)
FVB/NJ	MGP_FVBNJ_G0022421	protein coding gene	Chr16:14923160-14992969 (+)
LP/J	MGP_LPJ_G0022513	protein coding gene	Chr16:15489444-15555028 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022443	protein coding gene	Chr16:16345051-16416454 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023038	protein coding gene	Chr16:15475080-15546086 (+)
PWK/PhJ	MGP_PWKPhJ_G0021614	protein coding gene	Chr16:15134001-15203326 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021442	protein coding gene	Chr16:15432373-15500003 (+)
WSB/EiJ	MGP_WSBEiJ_G0021918	protein coding gene	Chr16:15470850-15539123 (+)

Human Ortholog

GNB1L, G protein subunit beta 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNB1L, G protein subunit beta 1 like
Synonyms

DGCRK3, FKSG1, GY2, WDR14, WDVCF
Links

HGNC:4397

NCBI Gene ID: 54584

neXtProt AC: NX_Q9BYB4

UniProt: Q9BYB4
Chr Location

22q11.21; chr22:19783223-19854939 (-) GRCh38

MGI Vertebrate Homology

Gnb1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNB1L
Gene Tree

Gnb1l

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References

6 with disease annotations

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
135 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

4
Gene trapped

10
Targeted

10
Genomic Mutations

10 involving Gnb1l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a gene trapped allele exhibit significantly reduced prepulse inhibition. Homozygotes die during early gestation.

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All GO Annotations

9
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

37
cDNA Data

13
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnb1l

ZFIN gnb1l

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All Sequences

102
RefSeq

34
UniProt

9
CCDS

CCDS28022.1, CCDS70695.1, CCDS88896.1

Ensembl

ENSMUSG00000000884 (Evidence)
NCBI Gene

13972

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000884	Ensembl Gene Model \| MGI Sequence Detail	67967	C57BL/6J	± kb
transcript	ENSMUST00000167778	Ensembl \| MGI Sequence Detail	3592	Not Applicable
polypeptide	ENSMUSP00000130371	Ensembl \| MGI Sequence Detail	357	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008096 guanine nucleotide-binding protein subunit beta-like protein 1

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 29

Genomic 10

cDNA 15

Primer pair 3

Other 1

Microarray probesets 3

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MGI:1927906

Summaries

All 166

Developmental Gene Expression 9

Diseases 6

Gene Ontology 4

Phenotypes 135
Earliest

J:54501 Lund J, et al., Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2. Mamm Genome. 1999 May;10(5):438-43
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Gnb1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137379	Chr16:18317534-18317566 (+)	87 bp
Tssr137380	Chr16:18317615-18317692 (+)	191 bp
Tssr137381	Chr16:18367464-18367472 (+)	50,005 bp
Tssr137382	Chr16:18367480-18367485 (+)	50,020 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24