Cdc45 MGI Mouse Gene Detail - MGI:1338073

Symbol

Cdc45
Name

cell division cycle 45
Synonyms

Cdc45l

Feature Type

protein coding gene
IDs

MGI:1338073
NCBI Gene: 12544
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:18599197-18630737 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 11.63 cM
Mapping Data

5 experiments

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338073	protein coding gene	Chr16:18599197-18632371 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022618	protein coding gene	Chr16:16036413-16073971 (-)
A/J	MGP_AJ_G0022579	protein coding gene	Chr16:15236198-15269031 (-)
AKR/J	MGP_AKRJ_G0022556	protein coding gene	Chr16:15852473-15886712 (-)
BALB/cJ	MGP_BALBcJ_G0022584	protein coding gene	Chr16:15388344-15420256 (-)
C3H/HeJ	MGP_C3HHeJ_G0022351	protein coding gene	Chr16:16004201-16038663 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023033	protein coding gene	Chr16:16354705-16393494 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020553	protein coding gene	Chr16:15272396-15303205 (-)
CAST/EiJ	MGP_CASTEiJ_G0021878	protein coding gene	Chr16:15906311-15936730 (-)
CBA/J	MGP_CBAJ_G0022320	protein coding gene	Chr16:17032057-17062926 (-)
DBA/2J	MGP_DBA2J_G0022452	protein coding gene	Chr16:15148400-15180451 (-)
FVB/NJ	MGP_FVBNJ_G0022427	protein coding gene	Chr16:15212292-15244864 (-)
LP/J	MGP_LPJ_G0022519	protein coding gene	Chr16:15789287-15821729 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022449	protein coding gene	Chr16:16667277-16702475 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023044	protein coding gene	Chr16:15770909-15805556 (-)
PWK/PhJ	MGP_PWKPhJ_G0021620	protein coding gene	Chr16:15444531-15475521 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021447	protein coding gene	Chr16:15691936-15764440 (-)
WSB/EiJ	MGP_WSBEiJ_G0021924	protein coding gene	Chr16:15797835-15830466 (-)

Human Ortholog

CDC45, cell division cycle 45

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC45, cell division cycle 45
Synonyms

CDC45L, CDC45L2, MGORS7, PORC-PI-1
Links

HGNC:1739

NCBI Gene ID: 8318

neXtProt AC: NX_O75419

UniProt: O75419
Chr Location

22q11.21; chr22:19479457-19520612 (+) GRCh38

MGI Vertebrate Homology

Cdc45 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDC45
Gene Tree

Cdc45

Diseases

1 with human CDC45 associations

				Human Disease	Mouse Models
				Meier-Gorlin syndrome 7 IDs Meier-Gorlin syndrome 7 DOID:0080518 OMIM:617063

Click on a disease name to see all genes associated with that disease.

References

4 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
65 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

6
Gene trapped

5
Targeted

9
Genomic Mutations

8 involving Cdc45
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available

Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

895
Tissues

98
cDNA Data

13
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDC45

Xenbase cdc45

ZFIN cdc45

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All Sequences

64
RefSeq

18
UniProt

5
CCDS

CCDS28027.1, CCDS49788.1

Ensembl

ENSMUSG00000000028 (Evidence)
NCBI Gene

12544

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000028	Ensembl Gene Model \| MGI Sequence Detail	31541	C57BL/6J	± kb
transcript	ENSMUST00000000028	Ensembl \| MGI Sequence Detail	2143	Not Applicable
polypeptide	ENSMUSP00000000028	Ensembl \| MGI Sequence Detail	566	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005215 CDC45-related protein

(term hierarchy)
InterPro Domains

IPR003874 CDC45 family

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All nucleic 32

Genomic 13

cDNA 13

Primer pair 6

Microarray probesets 3

Summaries

All 102

Developmental Gene Expression 17

Diseases 4

Gene Ontology 6

Phenotypes 65
Earliest

J:49568 McKie JM, et al., Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. Genome Res. 1998 Aug;8(8):834-41
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdc45:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140292	Chr16:18630753-18630775 (-)	-27 bp
Tssr140291	Chr16:18630388-18630393 (-)	346 bp
Tssr140290	Chr16:18630365-18630385 (-)	362 bp
Tssr140289	Chr16:18630334-18630359 (-)	390 bp
Tssr140288	Chr16:18603059-18603063 (-)	27,676 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24