Rnd2 MGI Mouse Gene Detail - MGI:1338755

Symbol

Rnd2
Name

Rho family GTPase 2
Synonyms

Arhn, Rohn

Feature Type

protein coding gene
IDs

MGI:1338755
NCBI Gene: 11858
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:101359001-101362679 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.12 cM, cytoband C-D
Mapping Data

2 experiments

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338755	protein coding gene	Chr11:101355825-101362679 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019205	protein coding gene	Chr11:104333006-104339637 (+)
A/J	MGP_AJ_G0019173	protein coding gene	Chr11:99946759-99953390 (+)
AKR/J	MGP_AKRJ_G0019142	protein coding gene	Chr11:103053330-103060162 (+)
BALB/cJ	MGP_BALBcJ_G0019147	protein coding gene	Chr11:100439287-100446119 (+)
C3H/HeJ	MGP_C3HHeJ_G0018956	protein coding gene	Chr11:103229884-103236515 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019596	protein coding gene	Chr11:107607680-107614464 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017222	protein coding gene	Chr11:97344776-97351427 (+)
CAST/EiJ	MGP_CASTEiJ_G0018510	protein coding gene	Chr11:104208715-104215310 (+)
CBA/J	MGP_CBAJ_G0018925	protein coding gene	Chr11:112036234-112043023 (+)
DBA/2J	MGP_DBA2J_G0019037	protein coding gene	Chr11:99468845-99475508 (+)
FVB/NJ	MGP_FVBNJ_G0019027	protein coding gene	Chr11:99011124-99017948 (+)
LP/J	MGP_LPJ_G0019106	protein coding gene	Chr11:104872581-104879068 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019058	protein coding gene	Chr11:111592164-111598786 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019634	protein coding gene	Chr11:103382982-103389583 (+)
PWK/PhJ	MGP_PWKPhJ_G0018273	protein coding gene	Chr11:100530947-100537960 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018065	protein coding gene	Chr11:103109621-103116246 (+)
WSB/EiJ	MGP_WSBEiJ_G0018559	protein coding gene	Chr11:103379437-103386061 (+)

Human Ortholog

RND2, Rho family GTPase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RND2, Rho family GTPase 2
Synonyms

ARHN, RHO7, RhoN
Links

HGNC:18315

NCBI Gene ID: 8153

neXtProt AC: NX_P52198

UniProt: P52198
Chr Location

17q21.31; chr17:43025231-43032041 (+) GRCh38

MGI Vertebrate Homology

Rnd2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RND2
Gene Tree

Rnd2

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Phenotype Summary

21 phenotypes from 3 alleles in 4 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

1
Gene trapped

6
Targeted

5
Genomic Mutations

1 involving Rnd2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Oligodenddrocyte-specific knock-out mice exhibit decreased myelin thickness at the onset of myelination but increased myelin thickness in the later period.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

18
cDNA Data

32
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RND2

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All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS25473.1

Ensembl

ENSMUSG00000001313 (Evidence)
NCBI Gene

11858

			Length	Strain/Species	Flank
genomic	11858	NCBI Gene Model \| MGI Sequence Detail	3679	C57BL/6J	± kb
transcript	NM_009708	RefSeq \| MGI Sequence Detail	1406	C57BL/6
polypeptide	Q9QYM5	UniProt \| EBI \| MGI Sequence Detail	227	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014062 Rho-related GTP-binding protein RhoN

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR041842 Rho-related GTP-binding protein RhoN

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain

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All nucleic 37

Genomic 1

cDNA 34

Primer pair 2

Microarray probesets 4

Summaries

All 63

Developmental Gene Expression 21

Gene Ontology 8

Phenotypes 15
Earliest

J:54016 Nishi M, et al., RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells. Brain Res Mol Brain Res. 1999 Apr 6;67(1):74-81
Latest

J:352990 Yang J, et al., Spatial transcriptome reveals the region-specific genes and pathways regulated by Satb2 in neocortical development. BMC Genomics. 2024 Aug 2;25(1):757

TSS for Rnd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105128	Chr11:101358964-101358975 (+)	-31 bp
Tssr105129	Chr11:101358990-101359001 (+)	-5 bp
Tssr105130	Chr11:101359007-101359018 (+)	12 bp
Tssr105131	Chr11:101359026-101359061 (+)	43 bp
Tssr105132	Chr11:101359062-101359075 (+)	68 bp
Tssr105133	Chr11:101359159-101359180 (+)	169 bp
Tssr105134	Chr11:101359181-101359199 (+)	189 bp
Tssr105135	Chr11:101360202-101360208 (+)	1,204 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24