Sec22b MGI Mouse Gene Detail - MGI:1338759 - SEC22 homolog B, vesicle trafficking protein

Symbol

Sec22b
Name

SEC22 homolog B, vesicle trafficking protein
Synonyms

4930564D15Rik, ERS-24, Sec22l1

Feature Type

protein coding gene
IDs

MGI:1338759
NCBI Gene: 20333
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:97808543-97829634 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 42.35 cM
Mapping Data

2 experiments

SNPs within 2kb

658 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338759	protein coding gene	Chr3:97808506-97830592 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027646	protein coding gene	Chr3:98873490-98897029 (+)
A/J	MGP_AJ_G0027608	protein coding gene	Chr3:95703748-95725835 (+)
AKR/J	MGP_AKRJ_G0027575	protein coding gene	Chr3:97997084-98019164 (+)
BALB/cJ	MGP_BALBcJ_G0027618	protein coding gene	Chr3:95507382-95529463 (+)
C3H/HeJ	MGP_C3HHeJ_G0027350	protein coding gene	Chr3:98267764-98289854 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028064	protein coding gene	Chr3:102546848-102568922 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025406	protein coding gene	Chr3:91961941-91984019 (+)
CAST/EiJ	MGP_CASTEiJ_G0026805	protein coding gene	Chr3:97564450-97586646 (+)
CBA/J	MGP_CBAJ_G0027325	protein coding gene	Chr3:106200239-106222325 (+)
DBA/2J	MGP_DBA2J_G0027468	protein coding gene	Chr3:95016033-95038866 (+)
FVB/NJ	MGP_FVBNJ_G0027437	protein coding gene	Chr3:93009126-93031188 (+)
LP/J	MGP_LPJ_G0027573	protein coding gene	Chr3:100131380-100154385 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027463	protein coding gene	Chr3:112282186-112304315 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028118	protein coding gene	Chr3:97622195-97644271 (+)
PWK/PhJ	MGP_PWKPhJ_G0026530	protein coding gene	Chr3:94905313-94927598 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026352	protein coding gene	Chr3:95901533-95923589 (+)
WSB/EiJ	MGP_WSBEiJ_G0026883	protein coding gene	Chr3:98061519-98083606 (+)

Human Ortholog

SEC22B, SEC22 homolog B, vesicle trafficking protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEC22B, SEC22 homolog B, vesicle trafficking protein
Synonyms

ERS-24, SEC22L1
Links

HGNC:10700

NCBI Gene ID: 9554

neXtProt AC: NX_O75396

UniProt: O75396
Chr Location

1p12; chr1:120150898-120176520 (-) GRCh38

MGI Vertebrate Homology

Sec22b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEC22B
Gene Tree

Sec22b

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Sec22b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Homozygous knockout has no effect on the development or function of lymphoid cells, nor on the process of antigen cross-presentation.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec22b

ZFIN sec22bb

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All Sequences

58
RefSeq

2
UniProt

5
CCDS

CCDS17658.1

Ensembl

ENSMUSG00000027879 (Evidence)
NCBI Gene

20333

			Length	Strain/Species	Flank
genomic	20333	NCBI Gene Model \| MGI Sequence Detail	21092	C57BL/6J	± kb
transcript	NM_011342	RefSeq \| MGI Sequence Detail	1815	C57BL/6
polypeptide	O08547	UniProt \| EBI \| MGI Sequence Detail	215	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014584 vesicle-trafficking protein SEC22b

(term hierarchy)
PDB

1IFQ, 5VNE, 5VNF, 5VNG, 5VNH, 5VNI, 5VNJ, 5VNK, 5VNL, 5VNM, 5VNN, 5VNO
InterPro Domains

IPR010908 Longin domain

IPR011012 Longin-like domain superfamily

IPR001388 Synaptobrevin-like

IPR044565 Vesicle-trafficking protein Sec22

IPR042855 v-SNARE, coiled-coil homology domain
GlyGen

O08547 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 19

Microarray probesets 6

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MGI:1922615, MGI:2139737, MGI:2140084, MGI:3035211

Summaries

All 53

Diseases 1

Gene Ontology 12

Phenotypes 16
Earliest

J:46012 Hay JC, et al., Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997 Apr 4;89(1):149-58
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sec22b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30804	Chr3:97808515-97808566 (+)	-2 bp
Tssr30805	Chr3:97829504-97829558 (+)	20,988 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24