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Colq Gene Detail
Summary
  • Symbol
    Colq
  • Name
    collagen like tail subunit of asymmetric acetylcholinesterase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338761
    NCBI Gene: 382864
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31245039-31299820 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.18 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1568 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338761
 protein coding gene Chr14:31245039-31313300 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021131
 protein coding gene Chr14:24713419-24783351 (-)
A/J MGP_AJ_G0021079
 protein coding gene Chr14:23779548-23848857 (-)
AKR/J MGP_AKRJ_G0021056
 protein coding gene Chr14:24902761-24974400 (-)
BALB/cJ MGP_BALBcJ_G0021083
 protein coding gene Chr14:23911378-23982169 (-)
C3H/HeJ MGP_C3HHeJ_G0020866
 protein coding gene Chr14:24774122-24844072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021515
 protein coding gene Chr14:25686735-25758543 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019078
 protein coding gene Chr14:23850788-23917925 (-)
CAST/EiJ MGP_CASTEiJ_G0020391
 protein coding gene Chr14:24558996-24638288 (-)
CBA/J MGP_CBAJ_G0020833
 protein coding gene Chr14:26661561-26736817 (-)
DBA/2J MGP_DBA2J_G0020955
 protein coding gene Chr14:23817410-23886097 (-)
FVB/NJ MGP_FVBNJ_G0020939
 protein coding gene Chr14:23770604-23839702 (-)
LP/J MGP_LPJ_G0021024
 protein coding gene Chr14:25038654-25109901 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020965
 protein coding gene Chr14:25914876-25997055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021548
 protein coding gene Chr14:24671269-24742553 (-)
PWK/PhJ MGP_PWKPhJ_G0020139
 protein coding gene Chr14:23274252-23350888 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019963
 protein coding gene Chr14:24277860-24357766 (-)
WSB/EiJ MGP_WSBEiJ_G0020446
 protein coding gene Chr14:24733369-24809268 (-)



Homology
more
  • Human Ortholog
    COLQ, collagen like tail subunit of asymmetric acetylcholinesterase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COLQ, collagen like tail subunit of asymmetric acetylcholinesterase
  • Synonyms
    CMS5, EAD
  • Links
    NCBI Gene ID: 8292
    neXtProt AC: NX_Q9Y215
    UniProt: Q9Y215

  • Chr Location
    3p25.1; chr3:15450133-15521751 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Colq mouse models; 1 with human COLQ associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit tremors, reduced body weight, lack of asymmetric forms of acetylcholinesterase and butyrylcholinesterase, and lethality prior to maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382864 NCBI Gene Model | MGI Sequence Detail 54782 C57BL/6J ±  kb
    transcript NM_009937 RefSeq | MGI Sequence Detail 2777 C57BL/6  
    polypeptide O35348 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:54000 Krejci E, et al., The mammalian gene of acetylcholinesterase-associated collagen. J Biol Chem. 1997 Sep 5;272(36):22840-7
    • Latest
      J:321979 Kurz J, et al., Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory