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Fhl2 Gene Detail
Summary
  • Symbol
    Fhl2
  • Name
    four and a half LIM domains 2
  • Synonyms
    SLIM3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338762
    NCBI Gene: 14200
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43162234-43236144 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 22.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2461 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338762
 protein coding gene Chr1:43162233-43237501 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015979
 protein coding gene Chr1:42093087-42136638 (-)
A/J MGP_AJ_G0015963
 protein coding gene Chr1:40829618-40870159 (-)
AKR/J MGP_AKRJ_G0015918
 protein coding gene Chr1:41363587-41404121 (-)
BALB/cJ MGP_BALBcJ_G0015917
 protein coding gene Chr1:40505628-40546496 (-)
C3H/HeJ MGP_C3HHeJ_G0015750
 protein coding gene Chr1:41746328-41786985 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016370
 protein coding gene Chr1:43826136-43868548 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014092
 protein coding gene Chr1:37661926-37691737 (-)
CAST/EiJ MGP_CASTEiJ_G0015331
 protein coding gene Chr1:41733456-41811311 (-)
CBA/J MGP_CBAJ_G0015722
 protein coding gene Chr1:45108390-45151681 (-)
DBA/2J MGP_DBA2J_G0015823
 protein coding gene Chr1:40106553-40148244 (-)
FVB/NJ MGP_FVBNJ_G0015825
 protein coding gene Chr1:39634180-39674860 (-)
LP/J MGP_LPJ_G0015893
 protein coding gene Chr1:42437851-42478906 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015845
 protein coding gene Chr1:47097636-47139308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016417
 protein coding gene Chr1:41577468-41621595 (-)
PWK/PhJ MGP_PWKPhJ_G0015114
 protein coding gene Chr1:39990461-40032146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014896
 protein coding gene Chr1:41571709-41662406 (-)
WSB/EiJ MGP_WSBEiJ_G0015393
 protein coding gene Chr1:41617247-41662043 (-)



Homology
more
  • Human Ortholog
    FHL2, four and a half LIM domains 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FHL2, four and a half LIM domains 2
  • Synonyms
    AAG11, DRAL, FHL-2, SLIM-3, SLIM3
  • Links
    NCBI Gene ID: 2274
    neXtProt AC: NX_Q14192
    UniProt: Q14192

  • Chr Location
    2q12.2; chr2:105357712-105438529 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation display osteopenia and osteoporosis; cardiovascular development is normal but cardiac hypertrophy develops in mutants in response to beta-adrenergic stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    171
  • cDNA Data
    66
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008136 Ensembl Gene Model | MGI Sequence Detail 73911 C57BL/6J ±  kb
    transcript ENSMUST00000008280 Ensembl | MGI Sequence Detail 1563 Not Applicable  
    polypeptide ENSMUSP00000008280 Ensembl | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007514 four and a half LIM domains protein 2
      (term hierarchy)
    • InterPro Domains
      IPR001781 Zinc finger, LIM-type
    • GlyGen
      O70433 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 66
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138652
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 26
      Gene Ontology 11
      Phenotypes 42
    • Earliest
      J:53041 Morgan MJ, et al., The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Biochem Biophys Res Commun. 1999 Feb 16;255(2):245-50
    • Latest
      J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory