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Purb Gene Detail
Summary
  • Symbol
    Purb
  • Name
    purine rich element binding protein B
  • Synonyms
    2310015K15Rik, Cager-2, D11Bwg0414e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338779
    NCBI Gene: 19291
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:6417599-6425917 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 4.16 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338779
 protein coding gene Chr11:6417599-6426076 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018024
 protein coding gene Chr11:3590235-3598453 (-)
A/J MGP_AJ_G0017997
 protein coding gene Chr11:3432536-3441401 (-)
AKR/J MGP_AKRJ_G0017961
 protein coding gene Chr11:3604857-3613176 (-)
BALB/cJ MGP_BALBcJ_G0017965
 protein coding gene Chr11:3442061-3450379 (-)
C3H/HeJ MGP_C3HHeJ_G0017778
 protein coding gene Chr11:3477705-3485951 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018417
 protein coding gene Chr11:3690805-3699123 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016075
 protein coding gene Chr11:3318317-3326615 (-)
CAST/EiJ MGP_CASTEiJ_G0017340
 protein coding gene Chr11:3474490-3482791 (-)
CBA/J MGP_CBAJ_G0017753
 protein coding gene Chr11:4111477-4119589 (-)
DBA/2J MGP_DBA2J_G0017863
 protein coding gene Chr11:3347966-3356234 (-)
FVB/NJ MGP_FVBNJ_G0017855
 protein coding gene Chr11:3366729-3374940 (-)
LP/J MGP_LPJ_G0017934
 protein coding gene Chr11:3662132-3670450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017881
 protein coding gene Chr11:3645653-3657070 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018457
 protein coding gene Chr11:3629068-3637386 (-)
PWK/PhJ MGP_PWKPhJ_G0017120
 protein coding gene Chr11:3382229-3390498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016917
 protein coding gene Chr11:3566830-3575106 (-)
WSB/EiJ MGP_WSBEiJ_G0017394
 protein coding gene Chr11:3445565-3453772 (-)



Homology
more
  • Human Ortholog
    PURB, purine rich element binding protein B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PURB, purine rich element binding protein B
  • Synonyms
    PURBETA
  • Links
    NCBI Gene ID: 5814
    neXtProt AC: NX_Q96QR8
    UniProt: Q96QR8

  • Chr Location
    7p13; chr7:44876299-44885530 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    2
  • cDNA Data
    14
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000094483 Ensembl Gene Model | MGI Sequence Detail 8319 C57BL/6J ±  kb
transcript ENSMUST00000179343 Ensembl | MGI Sequence Detail 8319 Not Applicable  
polypeptide ENSMUSP00000136957 Ensembl | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013495 transcriptional activator protein Pur-beta
    (term hierarchy)
  • InterPro Domains
    IPR006628 Purine-rich element binding protein family
  • GlyGen
    O35295 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 14
    Primer pair 2

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-34063, MGI:106370, MGI:1923687, MGI:3034759
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 13
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:343405 Ferris LA, et al., Purine-rich element binding protein B attenuates the coactivator function of myocardin by a novel molecular mechanism of smooth muscle gene repression. Mol Cell Biochem. 2021 Aug;476(8):2899-2916
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory