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Pex11a Gene Detail
Summary
  • Symbol
    Pex11a
  • Name
    peroxisomal biogenesis factor 11 alpha
  • Synonyms
    PEX11alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338788
    NCBI Gene: 18631
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79385705-79392879 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.12 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    233 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338788
 protein coding gene Chr7:79385705-79392879 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032394
 protein coding gene Chr7:81642008-81648996 (-)
A/J MGP_AJ_G0032373
 protein coding gene Chr7:79753430-79760604 (-)
AKR/J MGP_AKRJ_G0032309
 protein coding gene Chr7:81458085-81465073 (-)
BALB/cJ MGP_BALBcJ_G0032385
 protein coding gene Chr7:79445180-79452353 (-)
C3H/HeJ MGP_C3HHeJ_G0032098
 protein coding gene Chr7:82121802-82128790 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032877
 protein coding gene Chr7:84849491-84857806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029885
 protein coding gene Chr7:82291850-82298821 (-)
CAST/EiJ MGP_CASTEiJ_G0031426
 protein coding gene Chr7:72999487-73006484 (-)
CBA/J MGP_CBAJ_G0032064
 protein coding gene Chr7:87686519-87693693 (-)
DBA/2J MGP_DBA2J_G0032219
 protein coding gene Chr7:78322767-78329755 (-)
FVB/NJ MGP_FVBNJ_G0032174
 protein coding gene Chr7:78236070-78243244 (-)
LP/J MGP_LPJ_G0032300
 protein coding gene Chr7:82897015-82905465 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032211
 protein coding gene Chr7:87851583-87858570 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032895
 protein coding gene Chr7:80917656-80924644 (-)
PWK/PhJ MGP_PWKPhJ_G0031146
 protein coding gene Chr7:71497723-71504709 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030987
 protein coding gene Chr7:67919771-67926749 (-)
WSB/EiJ MGP_WSBEiJ_G0031544
 protein coding gene Chr7:81237337-81245495 (-)



Homology
more
  • Human Ortholog
    PEX11A, peroxisomal biogenesis factor 11 alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX11A, peroxisomal biogenesis factor 11 alpha
  • Synonyms
    hsPEX11p, PEX11alpha, PEX11-ALPHA, PMP28
  • Links
    NCBI Gene ID: 8800
    neXtProt AC: NX_O75192
    UniProt: O75192

  • Chr Location
    15q26.1; chr15:89677764-89690783 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit minor abnormalities of the mitochondria and peroxisomes. Mice homozygous for a different knock-out allele exhibit increased body weight, hepatic steatosis and fewer, smaller peroxisomes in hepatocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18631 NCBI Gene Model | MGI Sequence Detail 7175 C57BL/6J ±  kb
    transcript NM_011068 RefSeq | MGI Sequence Detail 2291 C57BL/6  
    polypeptide Q9Z211 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 43
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory