S100a11 MGI Mouse Gene Detail - MGI:1338798 - S100 calcium binding protein A11

Symbol

S100a11
Name

S100 calcium binding protein A11
Synonyms

cal, calgizzarin, Emap1, S100a14, S100c

Feature Type

protein coding gene
IDs

MGI:1338798
NCBI Gene: 20195
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:93427803-93433595 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.51 cM, cytoband E-F
Mapping Data

4 experiments

SNPs within 2kb

291 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338798	protein coding gene	Chr3:93427795-93433595 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027536	protein coding gene	Chr3:94023012-94028788 (+)
A/J	MGP_AJ_G0027501	protein coding gene	Chr3:91099223-91105105 (+)
AKR/J	MGP_AKRJ_G0027469	protein coding gene	Chr3:93208746-93214420 (+)
BALB/cJ	MGP_BALBcJ_G0027510	protein coding gene	Chr3:90852606-90858155 (+)
C3H/HeJ	MGP_C3HHeJ_G0027248	protein coding gene	Chr3:93417338-93424182 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027953	protein coding gene	Chr3:97588737-97594558 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025303	protein coding gene	Chr3:87692305-87697408 (+)
CAST/EiJ	MGP_CASTEiJ_G0026696	protein coding gene	Chr3:92867814-92874659 (+)
CBA/J	MGP_CBAJ_G0027224	protein coding gene	Chr3:100994583-101000392 (+)
DBA/2J	MGP_DBA2J_G0027361	protein coding gene	Chr3:90407367-90413191 (+)
FVB/NJ	MGP_FVBNJ_G0027330	protein coding gene	Chr3:88527118-88532962 (+)
LP/J	MGP_LPJ_G0027471	protein coding gene	Chr3:95274212-95281070 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027356	protein coding gene	Chr3:107232714-107239669 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028012	protein coding gene	Chr3:92924836-92930624 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0026245	protein coding gene	Chr3:91287607-91293173 (+)
WSB/EiJ	MGP_WSBEiJ_G0026779	protein coding gene	Chr3:93306551-93312249 (+)

Human Ortholog

S100A11, S100 calcium binding protein A11

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

S100A11, S100 calcium binding protein A11
Synonyms

HEL-S-43, MLN70, S100C
Links

HGNC:10488

NCBI Gene ID: 6282

neXtProt AC: NX_P31949

UniProt: P31949
Chr Location

1q21.3; chr1:152032506-152047907 (-) GRCh38

MGI Vertebrate Homology

S100a11 stringent orthology
1 human;1 mouse;3 rat;1 zebrafish
HCOP

vertebrate homology predictions: S100A11
Gene Tree

S100a11

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

9
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving S100a11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Mice dwith disruptions in this gene display no obvious phenotype abnormalities other than reduced sperm counts in males.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

23
cDNA Data

15
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase s100a11

ZFIN s100a11

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS38525.1

Ensembl

ENSMUSG00000027907 (Evidence)
NCBI Gene

20195

			Length	Strain/Species	Flank
genomic	20195	NCBI Gene Model \| MGI Sequence Detail	5793	C57BL/6J	± kb
transcript	NM_016740	RefSeq \| MGI Sequence Detail	504	C57BL/6
polypeptide	P50543	UniProt \| EBI \| MGI Sequence Detail	98	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014404 protein S100-A11

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR028482 Protein S100-A11

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

IPR001751 S100/Calcium binding protein 7/8-like, conserved site

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All nucleic 17

Genomic 1

cDNA 15

Primer pair 1

Microarray probesets 4

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MGD-MRK-19682, MGI:102775, MGI:1353430

Summaries

All 58

Developmental Gene Expression 8

Diseases 1

Gene Ontology 8

Phenotypes 14
Earliest

J:20657 Kao J, et al., Characterization of a novel tumor-derived cytokine. Endothelial-monocyte activating polypeptide II. J Biol Chem. 1994 Oct 7;269(40):25106-19
Latest

J:343286 Queen R, et al., Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777

TSS for S100a11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30415	Chr3:93427676-93427698 (+)	-116 bp
Tssr30416	Chr3:93427780-93427808 (+)	-9 bp
Tssr30417	Chr3:93433361-93433397 (+)	5,576 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24