S100a3 MGI Mouse Gene Detail - MGI:1338849 - S100 calcium binding protein A3

Symbol

S100a3
Name

S100 calcium binding protein A3
Synonyms

S100E

Feature Type

protein coding gene
IDs

MGI:1338849
NCBI Gene: 20197
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:90491966-90510009 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.26 cM, cytoband F1-F2
Mapping Data

4 experiments

SNPs within 2kb

591 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338849	protein coding gene	Chr3:90467571-90510922 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027472	protein coding gene	Chr3:90890837-90934216 (+)
A/J	MGP_AJ_G0027436	protein coding gene	Chr3:87855862-87899205 (+)
AKR/J	MGP_AKRJ_G0027401	protein coding gene	Chr3:90015572-90065360 (+)
BALB/cJ	MGP_BALBcJ_G0027445	protein coding gene	Chr3:87813312-87855940 (+)
C3H/HeJ	MGP_C3HHeJ_G0027187	protein coding gene	Chr3:90184268-90227096 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027891	protein coding gene	Chr3:94295738-94339285 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025244	protein coding gene	Chr3:83355126-83401434 (+)
CAST/EiJ	MGP_CASTEiJ_G0026633	protein coding gene	Chr3:90578958-90624332 (+)
CBA/J	MGP_CBAJ_G0027162	protein coding gene	Chr3:97504289-97545611 (+)
DBA/2J	MGP_DBA2J_G0027299	protein coding gene	Chr3:87224517-87264628 (+)
FVB/NJ	MGP_FVBNJ_G0027267	protein coding gene	Chr3:85553506-85595075 (+)
LP/J	MGP_LPJ_G0027408	protein coding gene	Chr3:91948036-91991640 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027288	protein coding gene	Chr3:103740640-103788521 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027950	protein coding gene	Chr3:89771138-89812860 (+)
PWK/PhJ	MGP_PWKPhJ_G0026367	protein coding gene	Chr3:87123138-87164085 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026187	protein coding gene	Chr3:88945360-88993761 (+)
WSB/EiJ	MGP_WSBEiJ_G0026715	protein coding gene	Chr3:90176731-90218717 (+)

Human Ortholog

S100A3, S100 calcium binding protein A3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

S100A3, S100 calcium binding protein A3
Synonyms

S100E
Links

HGNC:10493

NCBI Gene ID: 6274

neXtProt AC: NX_P33764

UniProt: P33764
Chr Location

1q21.3; chr1:153547329-153549258 (-) GRCh38

MGI Vertebrate Homology

S100a3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: S100A3
Gene Tree

S100a3

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving S100a3
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

66
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

20
UniProt

2
CCDS

CCDS17537.1

Ensembl

ENSMUSG00000001021 (Evidence)
NCBI Gene

20197

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001021	Ensembl Gene Model \| MGI Sequence Detail	18044	C57BL/6J	± kb
transcript	ENSMUST00000200508	Ensembl \| MGI Sequence Detail	587	Not Applicable
polypeptide	ENSMUSP00000142747	Ensembl \| MGI Sequence Detail	101	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014410 protein S100-A3

(term hierarchy)
InterPro Domains

IPR011992 EF-hand domain pair

IPR034325 S-100

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

IPR001751 S100/Calcium binding protein 7/8-like, conserved site

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All nucleic 67

Genomic 1

cDNA 66

Microarray probesets 4

Summaries

All 35

Developmental Gene Expression 1

Diseases 1

Gene Ontology 5

Phenotypes 8
Earliest

J:50719 Kizawa K, et al., Gene expression of mouse S100A3, a cysteine-rich calcium-binding protein, in developing hair follicle. J Invest Dermatol. 1998 Nov;111(5):879-86
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for S100a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30230	Chr3:90494562-90494578 (+)	2,604 bp
Tssr945	Chr3:90494582-90494597 (+)	2,624 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24