P2rx4 MGI Mouse Gene Detail - MGI:1338859 - purinergic receptor P2X, ligand-gated ion channel 4

Symbol

P2rx4
Name

purinergic receptor P2X, ligand-gated ion channel 4
Synonyms

D5Ertd444e, P2X4

Feature Type

protein coding gene
IDs

MGI:1338859
NCBI Gene: 18438
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:122845607-122867801 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.53 cM
Mapping Data

2 experiments

SNPs within 2kb

709 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338859	protein coding gene	Chr5:122845581-122867802 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030056	protein coding gene	Chr5:126352656-126377879 (+)
A/J	MGP_AJ_G0030021	protein coding gene	Chr5:121117906-121140166 (+)
AKR/J	MGP_AKRJ_G0029957	protein coding gene	Chr5:125022648-125047604 (+)
BALB/cJ	MGP_BALBcJ_G0030032	protein coding gene	Chr5:122466060-122488362 (+)
C3H/HeJ	MGP_C3HHeJ_G0029749	protein coding gene	Chr5:125648542-125673409 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030485	protein coding gene	Chr5:131233236-131258365 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027711	protein coding gene	Chr5:115725455-115746745 (+)
CAST/EiJ	MGP_CASTEiJ_G0029158	protein coding gene	Chr5:124733253-124776986 (+)
CBA/J	MGP_CBAJ_G0029719	protein coding gene	Chr5:136357260-136381874 (+)
DBA/2J	MGP_DBA2J_G0029869	protein coding gene	Chr5:121176086-121198280 (+)
FVB/NJ	MGP_FVBNJ_G0029825	protein coding gene	Chr5:120175647-120199580 (+)
LP/J	MGP_LPJ_G0029958	protein coding gene	Chr5:126887954-126916074 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029856	protein coding gene	Chr5:140079199-140101469 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030526	protein coding gene	Chr5:124620334-124642421 (+)
PWK/PhJ	MGP_PWKPhJ_G0028872	protein coding gene	Chr5:119960178-120004303 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028709	protein coding gene	Chr5:122333791-122357357 (+)
WSB/EiJ	MGP_WSBEiJ_G0029233	protein coding gene	Chr5:125284473-125309793 (+)

Human Ortholog

P2RX4, purinergic receptor P2X 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

P2RX4, purinergic receptor P2X 4
Synonyms

P2X4, P2X4R
Links

HGNC:8535

NCBI Gene ID: 5025

neXtProt AC: NX_Q99571

UniProt: Q99571
Chr Location

12q24.31; chr12:121210065-121234106 (+) GRCh38

MGI Vertebrate Homology

P2rx4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: P2RX4
Protein SuperFamily

P2X_purinoceptor
Gene Tree

P2rx4

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Phenotype Summary

13 phenotypes from 4 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
60 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving P2rx4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in hypertension, abnormal artery morphology, abnormal nitric oxide homeostasis, and impaired flow induced vascular remodeling and vasodilation.

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All GO Annotations

84
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

70
cDNA Data

16
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase p2rx4

ZFIN p2rx4a

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All Sequences

88
RefSeq

10
UniProt

10
CCDS

CCDS19654.2, CCDS80392.1, CCDS80393.1

Ensembl

ENSMUSG00000029470 (Evidence)
NCBI Gene

18438

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029470	Ensembl Gene Model \| MGI Sequence Detail	22195	C57BL/6J	± kb
transcript	ENSMUST00000031429	Ensembl \| MGI Sequence Detail	2702	Not Applicable
polypeptide	ENSMUSP00000031429	Ensembl \| MGI Sequence Detail	388	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000012191 P2X purinoceptor 4

(term hierarchy)
InterPro Domains

IPR003047 P2X4 purinoceptor

IPR001429 P2X purinoreceptor

IPR027309 P2X purinoreceptor extracellular domain superfamily
GlyGen

Q9JJX6 8 sites, 7 N-linked glycans (8 sites)

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 5

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MGI:1196264, MGI:2140926, MGI:2141234

Summaries

All 117

Developmental Gene Expression 8

Gene Ontology 13

Phenotypes 60
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:350992 Sierra-Marquez J, et al., Different localization of P2X4 and P2X7 receptors in native mouse lung - lack of evidence for a direct P2X4-P2X7 receptor interaction. Front Immunol. 2024;15:1425938

TSS for P2rx4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48710	Chr5:122845609-122845690 (+)	43 bp
Tssr48711	Chr5:122846022-122846051 (+)	430 bp
Tssr48712	Chr5:122856373-122856387 (+)	10,773 bp
Tssr48713	Chr5:122857988-122858000 (+)	12,387 bp
Tssr48714	Chr5:122858347-122858361 (+)	12,747 bp
Tssr48715	Chr5:122858404-122858416 (+)	12,803 bp
Tssr48716	Chr5:122858424-122858457 (+)	12,834 bp
Tssr48717	Chr5:122859691-122859707 (+)	14,092 bp
Tssr48718	Chr5:122859854-122859875 (+)	14,258 bp
Tssr48719	Chr5:122862664-122862684 (+)	17,067 bp
Tssr48720	Chr5:122863047-122863073 (+)	17,453 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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