Btrc MGI Mouse Gene Detail - MGI:1338871 - beta-transducin repeat containing protein

Symbol

Btrc
Name

beta-transducin repeat containing protein
Synonyms

beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb

Feature Type

protein coding gene
IDs

MGI:1338871
NCBI Gene: 12234
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr19:45352173-45518452 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.75 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

3476 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338871	protein coding gene	Chr19:45352119-45521782 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025187	protein coding gene	Chr19:44952244-45138201 (+)
A/J	MGP_AJ_G0025164	protein coding gene	Chr19:42762886-42934932 (+)
AKR/J	MGP_AKRJ_G0025132	protein coding gene	Chr19:44137059-44315789 (+)
BALB/cJ	MGP_BALBcJ_G0025158	protein coding gene	Chr19:42812388-42986624 (+)
C3H/HeJ	MGP_C3HHeJ_G0024918	protein coding gene	Chr19:44323794-44495039 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025601	protein coding gene	Chr19:46090453-46268501 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023015	protein coding gene	Chr19:42017219-42187671 (+)
CAST/EiJ	MGP_CASTEiJ_G0024383	protein coding gene	Chr19:44051756-44234672 (+)
CBA/J	MGP_CBAJ_G0024898	protein coding gene	Chr19:48394796-48583957 (+)
DBA/2J	MGP_DBA2J_G0025030	protein coding gene	Chr19:42575615-42746148 (+)
FVB/NJ	MGP_FVBNJ_G0024991	protein coding gene	Chr19:42356450-42528254 (+)
LP/J	MGP_LPJ_G0025116	protein coding gene	Chr19:44877456-45054320 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025022	protein coding gene	Chr19:47733713-47929506 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025659	protein coding gene	Chr19:44216355-44390159 (+)
PWK/PhJ	MGP_PWKPhJ_G0024132	protein coding gene	Chr19:42494717-42668995 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023936	protein coding gene	Chr19:42892633-43077497 (+)
WSB/EiJ	MGP_WSBEiJ_G0024453	protein coding gene	Chr19:44372965-44546907 (+)

Human Ortholog

BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
Synonyms

betaTrCP, BETA-TRCP, bTrCP, bTrCP1, FBW1A, FBXW1, FBXW1A, FWD1
Links

HGNC:1144

NCBI Gene ID: 8945

neXtProt AC: NX_Q9Y297

UniProt: Q9Y297
Chr Location

10q24.32; chr10:101354033-101557321 (+) GRCh38

MGI Vertebrate Homology

Btrc stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BTRC
Gene Tree

Btrc

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Phenotype Summary

17 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

3
Gene trapped

17
Targeted

9
Transgenic

1
Genomic Mutations

3 involving Btrc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.

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All GO Annotations

69
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1026
Tissues

223
cDNA Data

20
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase btrc

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All Sequences

149
RefSeq

76
UniProt

6
CCDS

CCDS29860.1, CCDS38002.1

Ensembl

ENSMUSG00000025217 (Evidence)
NCBI Gene

12234

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025217	Ensembl Gene Model \| MGI Sequence Detail	166280	C57BL/6J	± kb
transcript	ENSMUST00000065601	Ensembl \| MGI Sequence Detail	2978	Not Applicable
polypeptide	ENSMUSP00000070728	Ensembl \| MGI Sequence Detail	605	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004853 F-box/WD repeat-containing protein 1A

(term hierarchy)
InterPro Domains

IPR021977 D domain of beta-TrCP

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR020472 G-protein beta WD-40 repeat

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR050995 WD repeat and F-box domain-containing protein

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All nucleic 24

cDNA 20

Primer pair 4

Microarray probesets 4

Summaries

All 107

Developmental Gene Expression 16

Gene Ontology 20

Phenotypes 27
Earliest

J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
Latest

J:350459 McCallum-Loudeac J, et al., Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice. Hum Mol Genet. 2024 Apr 18;33(9):787-801

TSS for Btrc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156683	Chr19:45352183-45352270 (+)	54 bp
Tssr156684	Chr19:45352517-45352550 (+)	361 bp
Tssr156685	Chr19:45352628-45352643 (+)	463 bp
Tssr156686	Chr19:45433899-45433981 (+)	81,767 bp
Tssr156687	Chr19:45433987-45433997 (+)	81,819 bp
Tssr156688	Chr19:45461171-45461180 (+)	109,003 bp
Tssr156689	Chr19:45461194-45461210 (+)	109,029 bp
Tssr156690	Chr19:45461234-45461252 (+)	109,070 bp
Tssr156691	Chr19:45515804-45515833 (+)	163,646 bp
Tssr156692	Chr19:45516630-45516647 (+)	164,466 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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