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St14 Gene Detail
Summary
  • Symbol
    St14
  • Name
    suppression of tumorigenicity 14 (colon carcinoma)
  • Synonyms
    Epithin, matriptase, MT-SP1, Prss14, Tmprss14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338881
    NCBI Gene: 19143
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:31000698-31043149 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 16.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1286 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338881
 protein coding gene Chr9:30999886-31043149 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034516
 protein coding gene Chr9:28744140-28789862 (-)
A/J MGP_AJ_G0034494
 protein coding gene Chr9:28054189-28097540 (-)
AKR/J MGP_AKRJ_G0034420
 protein coding gene Chr9:28615078-28658752 (-)
BALB/cJ MGP_BALBcJ_G0034485
 protein coding gene Chr9:27917533-27961289 (-)
C3H/HeJ MGP_C3HHeJ_G0034197
 protein coding gene Chr9:28978625-29021746 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035006
 protein coding gene Chr9:29736831-29779131 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031936
 protein coding gene Chr9:26877799-26919995 (-)
CAST/EiJ MGP_CASTEiJ_G0033520
 protein coding gene Chr9:28830977-28877598 (-)
CBA/J MGP_CBAJ_G0034171
 protein coding gene Chr9:30708544-30758786 (-)
DBA/2J MGP_DBA2J_G0034328
 protein coding gene Chr9:28062859-28105061 (-)
FVB/NJ MGP_FVBNJ_G0034271
 protein coding gene Chr9:27467573-27509752 (-)
LP/J MGP_LPJ_G0034414
 protein coding gene Chr9:28944630-29005320 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034315
 protein coding gene Chr9:32379613-32423643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035026
 protein coding gene Chr9:28617338-28661990 (-)
PWK/PhJ MGP_PWKPhJ_G0033225
 protein coding gene Chr9:27996410-28039545 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033059
 protein coding gene Chr9:28712673-28756192 (-)
WSB/EiJ MGP_WSBEiJ_G0033635
 protein coding gene Chr9:28360864-28404671 (-)



Homology
more
  • Human Ortholog
    ST14, ST14 transmembrane serine protease matriptase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST14, ST14 transmembrane serine protease matriptase
  • Synonyms
    ARCI11, CAP3, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
  • Links
    NCBI Gene ID: 6768
    neXtProt AC: NX_Q9Y5Y6
    UniProt: Q9Y5Y6

  • Chr Location
    11q24.3; chr11:130159782-130210362 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with St14 mouse models; 1 with human ST14 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    82 phenotypes from 6 alleles in 8 genetic backgrounds
    23 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in pleiotropic defects affecting the development of the epidermis, hair follicles, and immune system. Mutant mice become dehydrated due to impaired epidermal barrier function and die within days of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    989
  • Tissues
    111
  • cDNA Data
    150
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031995 Ensembl Gene Model | MGI Sequence Detail 42452 C57BL/6J ±  kb
    transcript ENSMUST00000034478 Ensembl | MGI Sequence Detail 3259 Not Applicable  
    polypeptide ENSMUSP00000034478 Ensembl | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 163
      cDNA 154
      Primer pair 6
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:54857 Kim MG, et al., Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains. Immunogenetics. 1999 May;49(5):420-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory