Padi4 MGI Mouse Gene Detail - MGI:1338898 - peptidyl arginine deiminase, type IV

Symbol

Padi4
Name

peptidyl arginine deiminase, type IV
Synonyms

Pad4, PAD type IV, Pdi4

Feature Type

protein coding gene
IDs

MGI:1338898
NCBI Gene: 18602
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:140473176-140501547 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 72.34 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

297 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338898	protein coding gene	Chr4:140472819-140501547 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029029	protein coding gene	Chr4:143715664-143751314 (-)
A/J	MGP_AJ_G0028988	protein coding gene	Chr4:137493337-137522116 (-)
AKR/J	MGP_AKRJ_G0028940	protein coding gene	Chr4:141466390-141497306 (-)
BALB/cJ	MGP_BALBcJ_G0029012	protein coding gene	Chr4:138188041-138222822 (-)
C3H/HeJ	MGP_C3HHeJ_G0028726	protein coding gene	Chr4:141850423-141882923 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029453	protein coding gene	Chr4:148765385-148798067 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026724	protein coding gene	Chr4:130429337-130457243 (-)
CAST/EiJ	MGP_CASTEiJ_G0028158	protein coding gene	Chr4:140086927-140120719 (-)
CBA/J	MGP_CBAJ_G0028690	protein coding gene	Chr4:153008499-153053399 (-)
DBA/2J	MGP_DBA2J_G0028840	protein coding gene	Chr4:137895177-137929759 (-)
FVB/NJ	MGP_FVBNJ_G0028807	protein coding gene	Chr4:136988287-137019184 (-)
LP/J	MGP_LPJ_G0028939	protein coding gene	Chr4:143752796-143784779 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028833	protein coding gene	Chr4:156932554-156965357 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029491	protein coding gene	Chr4:141992802-142023558 (-)
PWK/PhJ	MGP_PWKPhJ_G0027879	protein coding gene	Chr4:134769996-134799330 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027704	protein coding gene	Chr4:137814486-137855938 (-)
WSB/EiJ	MGP_WSBEiJ_G0028236	protein coding gene	Chr4:142277192-142308580 (-)

Human Ortholog

PADI4, peptidyl arginine deiminase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PADI4, peptidyl arginine deiminase 4
Synonyms

PAD, PAD4, PADI5, PDI4, PDI5
Links

HGNC:18368

NCBI Gene ID: 23569

neXtProt AC: NX_Q9UM07

UniProt: Q9UM07
Chr Location

1p36.13

MGI Vertebrate Homology

Padi4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PADI4
Protein SuperFamily

Protein-arginine_deiminase
Gene Tree

Padi4

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Phenotype Summary

28 phenotypes from 5 alleles in 4 genetic backgrounds
97 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

3
Targeted

6
Genomic Mutations

3 involving Padi4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice are viable albeit reduced number than expected were born from heterozygous crosses, and shows decreased antibacterial immune responses. Mice homozygous for a different knock-out allele exhibit decreased weight loss in response to viral infection.

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All GO Annotations

36
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

102
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS18854.1

Ensembl

ENSMUSG00000025330 (Evidence)
NCBI Gene

18602

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025330	Ensembl Gene Model \| MGI Sequence Detail	28372	C57BL/6J	± kb
transcript	ENSMUST00000026381	Ensembl \| MGI Sequence Detail	2316	Not Applicable
polypeptide	ENSMUSP00000026381	Ensembl \| MGI Sequence Detail	666	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012222 protein-arginine deiminase type-4

(term hierarchy)
PDB

6MKD, 6MKR, 6MNG, 6MNM, 6MNN, 6MNO
EC

3.5.3.15
InterPro Domains

IPR008972 Cupredoxin

IPR038685 PAD, N-terminal domain superfamily

IPR004303 Protein-arginine deiminase

IPR036556 Protein-arginine deiminase, central domain superfamily

IPR013530 Protein-arginine deiminase, C-terminal

IPR013733 Protein-arginine deiminase (PAD), central domain

IPR013732 Protein-arginine deiminase (PAD), N-terminal

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 3

Summaries

All 146

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 97
Earliest

J:53035 Rus'd AA, et al., Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse. Eur J Biochem. 1999 Feb;259(3):660-9
Latest

J:358803 Tan H, et al., Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2. Free Radic Biol Med. 2024 Sep 12;224:540-553

TSS for Padi4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44280	Chr4:140501507-140501523 (-)	32 bp
Tssr44279	Chr4:140477913-140477929 (-)	23,626 bp
Tssr44278	Chr4:140477880-140477898 (-)	23,658 bp
Tssr44277	Chr4:140477857-140477874 (-)	23,681 bp
Tssr1360	Chr4:140477825-140477832 (-)	23,718 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24