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S100a10 Gene Detail
Summary
  • Symbol
    S100a10
  • Name
    S100 calcium binding protein A10 (calpactin)
  • Synonyms
    42C, CAL12, Cal1l, CLP11, p10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339468
    NCBI Gene: 20194
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:93462424-93471952 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.51 cM, cytoband F1-F2
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339468
 protein coding gene Chr3:93462387-93471952 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027537
 protein coding gene Chr3:94058698-94068277 (+)
A/J MGP_AJ_G0027502
 protein coding gene Chr3:91132857-91147871 (+)
AKR/J MGP_AKRJ_G0027470
 protein coding gene Chr3:93245666-93255234 (+)
BALB/cJ MGP_BALBcJ_G0027511
 protein coding gene Chr3:90886542-90896105 (+)
C3H/HeJ MGP_C3HHeJ_G0027249
 protein coding gene Chr3:93458466-93469157 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027954
 protein coding gene Chr3:97637877-97647436 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025304
 protein coding gene Chr3:87725324-87734842 (+)
CAST/EiJ MGP_CASTEiJ_G0026697
 protein coding gene Chr3:92912995-92922551 (+)
CBA/J MGP_CBAJ_G0027225
 protein coding gene Chr3:101038214-101049214 (+)
DBA/2J MGP_DBA2J_G0027362
 protein coding gene Chr3:90439964-90450500 (+)
FVB/NJ MGP_FVBNJ_G0027331
 protein coding gene Chr3:88562659-88572518 (+)
LP/J MGP_LPJ_G0027472
 protein coding gene Chr3:95309848-95319443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027357
 protein coding gene Chr3:107274031-107283600 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028013
 protein coding gene Chr3:92963739-92973294 (+)
PWK/PhJ MGP_PWKPhJ_G0026425
 protein coding gene Chr3:90311993-90321964 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026246
 protein coding gene Chr3:91324028-91336423 (+)
WSB/EiJ MGP_WSBEiJ_G0026780
 protein coding gene Chr3:93343870-93353429 (+)



Homology
more
  • Human Ortholog
    S100A10, S100 calcium binding protein A10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S100A10, S100 calcium binding protein A10
  • Synonyms
    42C, ANX2L, ANX2LG, Ca[1], CAL1L, CLP11, GP11, p10, P11
  • Links
    NCBI Gene ID: 6281
    neXtProt AC: NX_P60903
    UniProt: P60903

  • Chr Location
    1q21.3; chr1:151982915-151993859 (-)  GRCh38
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    29
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving S100a10
  • Find Mice (IMSR)
    34 strains or lines available
Mice homozygous for a knock-out allele display a depression-like phenotype, decreased responsiveness to 5-HT1B receptor agonists, and reduced behavioral reactions to an antidepressant.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1328
  • Tissues
    223
  • cDNA Data
    149
  • Literature Summary
    18
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20194 NCBI Gene Model | MGI Sequence Detail 9529 C57BL/6J ±  kb
transcript NM_009112 RefSeq | MGI Sequence Detail 650 ZRU/MplStud  
polypeptide P08207 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 155
    cDNA 150
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1728, MGI:2139574, MGI:2139857, MGI:88247
References
more
  • Summaries
    All 102
    Developmental Gene Expression 18
    Diseases 1
    Gene Ontology 10
    Phenotypes 36
  • Earliest
    J:8809 Saris CJ, et al., cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). J Biol Chem. 1987 Aug 5;262(22):10663-71
  • Latest
    J:344855 Liu H, et al., S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice. Int Immunopharmacol. 2024 Jan 16;128:111499
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory