Pak3 MGI Mouse Gene Detail - MGI:1339656 - p21 (RAC1) activated kinase 3

Symbol

Pak3
Name

p21 (RAC1) activated kinase 3
Synonyms

PAK-3

Feature Type

protein coding gene
IDs

MGI:1339656
NCBI Gene: 18481
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

ChrX:142301587-142580792 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 64.50 cM
Mapping Data

3 experiments

SNPs within 2kb

5904 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339656	protein coding gene	ChrX:142301370-142580792 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036155	protein coding gene	ChrX:141072232-141361859 (+)
A/J	MGP_AJ_G0036132	protein coding gene	ChrX:140412113-140687644 (+)
AKR/J	MGP_AKRJ_G0036058	protein coding gene	ChrX:144956789-145245114 (+)
BALB/cJ	MGP_BALBcJ_G0036123	protein coding gene	ChrX:138635016-138921504 (+)
C3H/HeJ	MGP_C3HHeJ_G0035831	protein coding gene	ChrX:141150435-141435508 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036646	protein coding gene	ChrX:145014220-145308036 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033470	protein coding gene	ChrX:131934602-132215545 (+)
CAST/EiJ	MGP_CASTEiJ_G0035122	protein coding gene	ChrX:121845616-122131762 (+)
CBA/J	MGP_CBAJ_G0035808	protein coding gene	ChrX:149593814-149877803 (+)
DBA/2J	MGP_DBA2J_G0035966	protein coding gene	ChrX:139507947-139783897 (+)
FVB/NJ	MGP_FVBNJ_G0035900	protein coding gene	ChrX:138704430-138979141 (+)
LP/J	MGP_LPJ_G0036057	protein coding gene	ChrX:142019596-142304389 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035936	protein coding gene	ChrX:157273817-157588050 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036683	protein coding gene	ChrX:140383002-140657539 (+)
PWK/PhJ	MGP_PWKPhJ_G0034816	protein coding gene	ChrX:118647512-118927589 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034641	protein coding gene	ChrX:122383372-122677605 (+)
WSB/EiJ	MGP_WSBEiJ_G0035257	protein coding gene	ChrX:138729328-139018517 (+)

Human Ortholog

PAK3, p21 (RAC1) activated kinase 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAK3, p21 (RAC1) activated kinase 3
Synonyms

ARA, beta-PAK, bPAK, MRX30, MRX47, OPHN3, PAK-3, PAK3beta, XLID30
Links

HGNC:8592

NCBI Gene ID: 5063

neXtProt AC: NX_O75914

UniProt: O75914
Chr Location

Xq23; chrX:110944285-111227361 (+) GRCh38

MGI Vertebrate Homology

Pak3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PAK3
Gene Tree

Pak3

Diseases

1 with Pak3 mouse models; 1 with human PAK3 associations

Human Disease

Mouse Models

non-syndromic X-linked intellectual disability 30

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Targeted

6
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one knock-out allele display a selective impairment in hippocampal late-phase long-term potentiation, and deficits in learning and memory.

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All GO Annotations

64
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

94
cDNA Data

8
Literature Summary

27

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pak3

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All Sequences

99
RefSeq

42
UniProt

7
CCDS

CCDS30454.1, CCDS57779.1

Ensembl

ENSMUSG00000031284 (Evidence)
NCBI Gene

18481

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031284	Ensembl Gene Model \| MGI Sequence Detail	279206	C57BL/6J	± kb
transcript	ENSMUST00000033640	Ensembl \| MGI Sequence Detail	8348	Not Applicable
polypeptide	ENSMUSP00000033640	Ensembl \| MGI Sequence Detail	559	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012242 serine/threonine-protein kinase PAK 3

(term hierarchy)
PDB

1EES
EC

2.7.11.1
InterPro Domains

IPR000095 CRIB domain

IPR036936 CRIB domain superfamily

IPR035063 p21-activated kinase 3, catalytic domain

IPR033923 p21 activated kinase binding domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR050285 STE20 Serine/Threonine-Protein Kinase
GlyGen

Q61036 1 site, 1 N-linked glycan (1 site)

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All nucleic 17

Genomic 1

cDNA 12

Primer pair 2

Other 2

Microarray probesets 3

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MGD-MRK-33717, MGI:106033

Summaries

All 76

Developmental Gene Expression 27

Diseases 1

Gene Ontology 15

Phenotypes 13
Earliest

J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
Latest

J:357470 Hu B, et al., PAK2 is necessary for myelination in the peripheral nervous system. Brain. 2024 May 3;147(5):1809-1821

TSS for Pak3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162258	ChrX:142301396-142301410 (+)	-184 bp
Tssr162259	ChrX:142301509-142301524 (+)	-70 bp
Tssr162260	ChrX:142301535-142301552 (+)	-43 bp
Tssr162261	ChrX:142301558-142301570 (+)	-23 bp
Tssr162262	ChrX:142301572-142301595 (+)	-3 bp
Tssr162263	ChrX:142301667-142301699 (+)	96 bp
Tssr162264	ChrX:142301702-142301713 (+)	121 bp
Tssr162265	ChrX:142301722-142301733 (+)	141 bp
Tssr162266	ChrX:142447329-142447350 (+)	145,753 bp
Tssr162267	ChrX:142447353-142447358 (+)	145,769 bp
Tssr162268	ChrX:142447361-142447395 (+)	145,791 bp
Tssr162269	ChrX:142468045-142468069 (+)	166,470 bp
Tssr162270	ChrX:142468073-142468081 (+)	166,490 bp
Tssr5697	ChrX:142468088-142468096 (+)	166,505 bp
Tssr162271	ChrX:142567228-142567231 (+)	265,643 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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