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Csf1 Gene Detail
Summary
  • Symbol
    Csf1
  • Name
    colony stimulating factor 1 (macrophage)
  • Synonyms
    BAP025, colony-stimulating factor-1, CSF-1, Csfm, M-CSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339753
    NCBI Gene: 12977
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107648364-107667785 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3,
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339753
 protein coding gene Chr3:107648364-107668048 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027755
 protein coding gene Chr3:109239892-109259311 (-)
A/J MGP_AJ_G0027715
 protein coding gene Chr3:105792077-105811498 (-)
AKR/J MGP_AKRJ_G0027680
 protein coding gene Chr3:108366803-108386222 (-)
BALB/cJ MGP_BALBcJ_G0027727
 protein coding gene Chr3:105480821-105500256 (-)
C3H/HeJ MGP_C3HHeJ_G0027457
 protein coding gene Chr3:108707975-108727394 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028171
 protein coding gene Chr3:113333300-113353186 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025509
 protein coding gene Chr3:101940067-101959362 (-)
CAST/EiJ MGP_CASTEiJ_G0026913
 protein coding gene Chr3:108089209-108108647 (-)
CBA/J MGP_CBAJ_G0027432
 protein coding gene Chr3:117162151-117181608 (-)
DBA/2J MGP_DBA2J_G0027574
 protein coding gene Chr3:104976833-104996287 (-)
FVB/NJ MGP_FVBNJ_G0027542
 protein coding gene Chr3:102861135-102880555 (-)
LP/J MGP_LPJ_G0027681
 protein coding gene Chr3:110669288-110688707 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027572
 protein coding gene Chr3:123264727-123284148 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028226
 protein coding gene Chr3:107955801-107975310 (-)
PWK/PhJ MGP_PWKPhJ_G0026639
 protein coding gene Chr3:104719118-104738652 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026459
 protein coding gene Chr3:106084303-106103712 (-)
WSB/EiJ MGP_WSBEiJ_G0026993
 protein coding gene Chr3:108483017-108502463 (-)



Homology
more
  • Human Ortholog
    CSF1, colony stimulating factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSF1, colony stimulating factor 1
  • Synonyms
    CSF-1, MCSF, PG-M-CSF
  • Links
    NCBI Gene ID: 1435
    neXtProt AC: NX_P09603
    UniProt: P09603

  • Chr Location
    1p13.3; chr1:109910242-109930992 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Csf1 mouse models; 1 with human CSF1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    131 phenotypes from 3 alleles in 6 genetic backgrounds
    38 phenotypes from multigenic genotypes
    3 images
    295 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit lack of incisors, a broad domed skull, short thick limb bones with reduced marrow cavities, impaired hearing and vision, and reduced fertility in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    73
  • cDNA Data
    102
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014599 Ensembl Gene Model | MGI Sequence Detail 19422 C57BL/6J ±  kb
    transcript ENSMUST00000014743 Ensembl | MGI Sequence Detail 4176 Not Applicable  
    polypeptide ENSMUSP00000014743 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 4
      cDNA 103
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13034, MGD-MRK-2191, MGI:2140102, MGI:5425514, MGI:88534
    References
    more
    • Summaries
      All 503
      Developmental Gene Expression 30
      Diseases 2
      Gene Ontology 25
      Phenotypes 295
    • Earliest
      J:5149 Ruddle FH, et al., Esterase genetics in Mus musculus: expression, linkage, and polymorphism of locus Es-2. Genetics. 1969 Jun;62(2):393-9
    • Latest
      J:357895 Houchen CJ, et al., TGF-beta signaling in the cranial neural crest affects late-stage mandibular bone resorption and length. Front Physiol. 2024;15:1435594
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory