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Csf2rb2 Gene Detail
Summary
  • Symbol
    Csf2rb2
  • Name
    colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
  • Synonyms
    AIC2A, BetaIl3, Bil3, Il3r, Il3rb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339760
    NCBI Gene: 12984
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78166707-78189921 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.22 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    948 from dbSNP Build 142
  • Strain Annotations
    6
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339760
 protein coding gene Chr15:78166707-78189921 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0021999
 protein coding gene Chr15:75716240-75742306 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0019978
 protein coding gene Chr15:72279547-72305435 (-)
CAST/EiJ MGP_CASTEiJ_G0021298
 protein coding gene Chr15:78493462-78528943 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021040
 protein coding gene Chr15:75298532-75328749 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020877
 protein coding gene Chr15:77725545-77743090 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor subunit beta
  • Synonyms
    betaGMR, CD131, CDw131, IL3RB, IL5RB, SMDP5
  • Links
    NCBI Gene ID: 1439
    neXtProt AC: NX_P32927
    UniProt: P32927

  • Chr Location
    22q12.3; chr22:36913628-36940439 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CSF2RB associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are apparently normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    7
  • cDNA Data
    54
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12984 NCBI Gene Model | MGI Sequence Detail 23215 C57BL/6J ±  kb
transcript NM_007781 RefSeq | MGI Sequence Detail 4740 ZRU/MplStud  
polypeptide P26954 UniProt | EBI | MGI Sequence Detail 878 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000006203 interleukin-3 receptor class 2 beta chain
    (term hierarchy)
  • PDB
    4QQV
  • InterPro Domains
    IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
    IPR048668 Cytokine receptor common subunit beta, N-terminal
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR015152 Growth hormone/erythropoietin receptor, ligand binding
    IPR013783 Immunoglobulin-like fold
    IPR015373 Interferon/interleukin receptor domain
    IPR003531 Short hematopoietin receptor, family 1, conserved site
  • GlyGen
    P26954 2 sites
Molecular
Reagents
less
  • All nucleic 64
    Genomic 3
    cDNA 57
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11380, MGD-MRK-11382, MGD-MRK-11384, MGD-MRK-2189, MGI:96555
References
more
  • Summaries
    All 88
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 4
    Phenotypes 45
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:336637 Charlet A, et al., The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML. Leukemia. 2022 Mar;36(3):701-711
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory