P2rx7 MGI Mouse Gene Detail - MGI:1339957 - purinergic receptor P2X, ligand-gated ion channel, 7

Symbol

P2rx7
Name

purinergic receptor P2X, ligand-gated ion channel, 7
Synonyms

P2X(7), P2X7R, P2X7 receptor

Feature Type

protein coding gene
IDs

MGI:1339957
NCBI Gene: 18439
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:122781974-122829495 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.50 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

1644 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339957	protein coding gene	Chr5:122781974-122830399 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030055	protein coding gene	Chr5:126288598-126337736 (+)
A/J	MGP_AJ_G0030020	protein coding gene	Chr5:121055250-121102671 (+)
AKR/J	MGP_AKRJ_G0029956	protein coding gene	Chr5:124950938-125007491 (+)
BALB/cJ	MGP_BALBcJ_G0030031	protein coding gene	Chr5:122403411-122451047 (+)
C3H/HeJ	MGP_C3HHeJ_G0029748	protein coding gene	Chr5:125582236-125632662 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030484	protein coding gene	Chr5:131155961-131203500 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027710	protein coding gene	Chr5:115659935-115707659 (+)
CAST/EiJ	MGP_CASTEiJ_G0029157	protein coding gene	Chr5:124675806-124717717 (+)
CBA/J	MGP_CBAJ_G0029718	protein coding gene	Chr5:136282112-136335176 (+)
DBA/2J	MGP_DBA2J_G0029868	protein coding gene	Chr5:121111174-121159625 (+)
FVB/NJ	MGP_FVBNJ_G0029824	protein coding gene	Chr5:120105503-120160123 (+)
LP/J	MGP_LPJ_G0029957	protein coding gene	Chr5:126825843-126872975 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029855	protein coding gene	Chr5:140013081-140062147 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030525	protein coding gene	Chr5:124554753-124604266 (+)
PWK/PhJ	MGP_PWKPhJ_G0028871	protein coding gene	Chr5:119895737-119943526 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028708	protein coding gene	Chr5:122268416-122317580 (+)
WSB/EiJ	MGP_WSBEiJ_G0029232	protein coding gene	Chr5:125213546-125264903 (+)

Human Ortholog

P2RX7, purinergic receptor P2X 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

P2RX7, purinergic receptor P2X 7
Synonyms

P2X7
Links

HGNC:8537

NCBI Gene ID: 5027

neXtProt AC: NX_Q99572

UniProt: Q99572
Chr Location

12q24.31; chr12:121132819-121188032 (+) GRCh38

MGI Vertebrate Homology

P2rx7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: P2RX7
Gene Tree

P2rx7

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Phenotype Summary

24 phenotypes from 6 alleles in 11 genetic backgrounds
10 phenotypes from multigenic genotypes
344 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Spontaneous

2
Targeted

14
Genomic Mutations

3 involving P2rx7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are fertile and viable with no obvious phenotypic abnormality. Cellular responses of macrophages to extracellular ATP are frequently normal however. In addition, long bones are thinner than normal in adult mice.

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All GO Annotations

198
GO References

46

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

11
cDNA Data

30
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

75
RefSeq

10
UniProt

11
CCDS

CCDS19651.1, CCDS19652.1, CCDS19653.1, CCDS51644.1, CCDS89983.1

Ensembl

ENSMUSG00000029468 (Evidence)
NCBI Gene

18439

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029468	Ensembl Gene Model \| MGI Sequence Detail	47522	C57BL/6J	± kb
transcript	ENSMUST00000100737	Ensembl \| MGI Sequence Detail	4936	Not Applicable
polypeptide	ENSMUSP00000098303	Ensembl \| MGI Sequence Detail	595	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000012194 P2X purinoceptor 7

(term hierarchy)
InterPro Domains

IPR003050 P2X7 purinoceptor

IPR001429 P2X purinoreceptor

IPR046815 P2X purinoreceptor 7, intracellular domain

IPR027309 P2X purinoreceptor extracellular domain superfamily
GlyGen

Q9Z1M0 5 sites, 8 N-linked glycans (4 sites)

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All nucleic 33

cDNA 31

Primer pair 2

Microarray probesets 7

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MGI:2140909

Summaries

All 462

Developmental Gene Expression 6

Gene Ontology 46

Phenotypes 344
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:359481 Dautan D, et al., Cortico-cortical transfer of socially derived information gates emotion recognition. Nat Neurosci. 2024 Jul;27(7):1318-1332

TSS for P2rx7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48704	Chr5:122781941-122782047 (+)	20 bp
Tssr48705	Chr5:122786397-122786409 (+)	4,429 bp
Tssr48706	Chr5:122788439-122788456 (+)	6,474 bp
Tssr48707	Chr5:122788468-122788475 (+)	6,498 bp
Tssr48708	Chr5:122793654-122793658 (+)	11,682 bp
Tssr48709	Chr5:122820954-122820974 (+)	38,990 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24