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Cth Gene Detail
Summary
  • Symbol
    Cth
  • Name
    cystathionine gamma lyase
  • Synonyms
    0610010I13Rik, CSE, MGC:28655
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339968
    NCBI Gene: 107869
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:157599885-157630714 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 81.55 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    802 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339968
 protein coding gene Chr3:157599885-157630718 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028013
 protein coding gene Chr3:162043001-162075477 (-)
A/J MGP_AJ_G0027971
 protein coding gene Chr3:156142575-156174067 (-)
AKR/J MGP_AKRJ_G0027937
 protein coding gene Chr3:160284892-160318720 (-)
BALB/cJ MGP_BALBcJ_G0027983
 protein coding gene Chr3:155947325-155977690 (-)
C3H/HeJ MGP_C3HHeJ_G0027713
 protein coding gene Chr3:160691555-160722952 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028426
 protein coding gene Chr3:167345495-167379557 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025765
 protein coding gene Chr3:150757534-150788009 (-)
CAST/EiJ MGP_CASTEiJ_G0027166
 protein coding gene Chr3:160837909-160867428 (-)
CBA/J MGP_CBAJ_G0027688
 protein coding gene Chr3:173304026-173335369 (-)
DBA/2J MGP_DBA2J_G0027828
 protein coding gene Chr3:155190511-155221156 (-)
FVB/NJ MGP_FVBNJ_G0027795
 protein coding gene Chr3:152539535-152569908 (-)
LP/J MGP_LPJ_G0027939
 protein coding gene Chr3:163380266-163411663 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027828
 protein coding gene Chr3:181888333-181923382 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028485
 protein coding gene Chr3:159970140-160001026 (-)
PWK/PhJ MGP_PWKPhJ_G0026889
 protein coding gene Chr3:155116706-155147890 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026717
 protein coding gene Chr3:158192872-158221394 (-)
WSB/EiJ MGP_WSBEiJ_G0027246
 protein coding gene Chr3:160930829-160963776 (-)



Homology
more
  • Human Ortholog
    CTH, cystathionine gamma-lyase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTH, cystathionine gamma-lyase
  • Synonyms
    CGL, CSE
  • Links
    NCBI Gene ID: 1491
    neXtProt AC: NX_P32929
    UniProt: P32929

  • Chr Location
    1p31.1; chr1:70411218-70439851 (+)  GRCh38
  • MGI Vertebrate Homology
    Cth stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: CTH
  • Protein SuperFamily
    CGS
  • Gene Tree
    Cth
Human Diseases
more
  • Diseases
    1 with Cth mouse models; 2 with human CTH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hypertension associated with impaired endothelium-dependent vasorelaxation. Mice homozygous for another knock-out allele exhibit normal blood pressure but sensitivty to a low cysteine diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    932
  • Tissues
    125
  • cDNA Data
    77
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028179 Ensembl Gene Model | MGI Sequence Detail 30830 C57BL/6J ±  kb
    transcript ENSMUST00000118539 Ensembl | MGI Sequence Detail 1815 Not Applicable  
    polypeptide ENSMUSP00000113672 Ensembl | MGI Sequence Detail 398 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006004 cystathionine gamma-lyase
      (term hierarchy)
    • EC
      4.4.1.1, 4.4.1.2
    • InterPro Domains
      IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      Q8VCN5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 79
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917588, MGI:2139663, MGI:2384807
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 12
      Phenotypes 88
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:358077 Hu YT, et al., Cystathionine gamma-lyase-derived H(2)S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase. Acta Pharmacol Sin. 2024 Nov;45(11):2366-2379
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory