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Ilf3 Gene Detail
Summary
  • Symbol
    Ilf3
  • Name
    interleukin enhancer binding factor 3
  • Synonyms
    NF90
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339973
    NCBI Gene: 16201
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21279167-21316657 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.78 cM, cytoband A4-A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    700 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339973
 protein coding gene Chr9:21278964-21316659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034451
 protein coding gene Chr9:18577798-18618562 (+)
A/J MGP_AJ_G0034429
 protein coding gene Chr9:18257101-18295992 (+)
AKR/J MGP_AKRJ_G0034356
 protein coding gene Chr9:18595554-18637725 (+)
BALB/cJ MGP_BALBcJ_G0034420
 protein coding gene Chr9:18147309-18184872 (+)
C3H/HeJ MGP_C3HHeJ_G0034132
 protein coding gene Chr9:18902556-18942974 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034941
 protein coding gene Chr9:19335541-19373304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031871
 protein coding gene Chr9:17382848-17420398 (+)
CAST/EiJ MGP_CASTEiJ_G0033455
 protein coding gene Chr9:18729246-18766639 (+)
CBA/J MGP_CBAJ_G0034105
 protein coding gene Chr9:20053005-20100100 (+)
DBA/2J MGP_DBA2J_G0034264
 protein coding gene Chr9:18227918-18269897 (+)
FVB/NJ MGP_FVBNJ_G0034207
 protein coding gene Chr9:17759585-17798269 (+)
LP/J MGP_LPJ_G0034349
 protein coding gene Chr9:18740746-18778531 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034250
 protein coding gene Chr9:21646346-21683470 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034961
 protein coding gene Chr9:18558592-18596171 (+)
PWK/PhJ MGP_PWKPhJ_G0033161
 protein coding gene Chr9:18219479-18258009 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032995
 protein coding gene Chr9:18607132-18645543 (+)
WSB/EiJ MGP_WSBEiJ_G0033570
 protein coding gene Chr9:18271514-18312821 (+)



Homology
more
  • Human Ortholog
    ILF3, interleukin enhancer binding factor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ILF3, interleukin enhancer binding factor 3
  • Synonyms
    CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, MPP4110, NF110, NF110b, NF90, NF90a, NF90b, NF90c, NF90ctv, NFAR, NFAR-1, NFAR110, NFAR-2, NFAR2, NFAR90, NF-AT-90, TCP110, TCP80
  • Links
    NCBI Gene ID: 3609
    neXtProt AC: NX_Q12906
    UniProt: Q12906

  • Chr Location
    19p13.2; chr19:10654304-10692400 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born small and weak, show tachypnea and multi-organ apoptosis, and die neonatally due to neuromuscular respiratory failure. The diaphragm and other skeletal muscles show disorganization and paucity of myofibers,myocyte degeneration and elevated apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    152
  • cDNA Data
    211
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032178 Ensembl Gene Model | MGI Sequence Detail 37491 C57BL/6J ±  kb
    transcript ENSMUST00000214758 Ensembl | MGI Sequence Detail 3177 Not Applicable  
    polypeptide ENSMUSP00000151032 Ensembl | MGI Sequence Detail 911 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 215
      cDNA 213
      Primer pair 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:54438 Buaas FW, et al., Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins. Mamm Genome. 1999 May;10(5):451-6
    • Latest
      J:359006 Wang ZY, et al., Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice. Nat Commun. 2024 Aug 23;15(1):7249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory