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Mettl1 Gene Detail
Summary
  • Symbol
    Mettl1
  • Name
    methyltransferase 1, tRNA methylguanosine
  • Synonyms
    2810012D02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339986
    NCBI Gene: 17299
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:126877287-126882234 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339986
 protein coding gene Chr10:126877283-126882234 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017801
 protein coding gene Chr10:130617472-130623601 (+)
A/J MGP_AJ_G0017776
 protein coding gene Chr10:125385392-125390342 (+)
AKR/J MGP_AKRJ_G0017739
 protein coding gene Chr10:129096088-129102027 (+)
BALB/cJ MGP_BALBcJ_G0017740
 protein coding gene Chr10:125792711-125798016 (+)
C3H/HeJ MGP_C3HHeJ_G0017564
 protein coding gene Chr10:129230370-129238347 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018195
 protein coding gene Chr10:135046512-135051653 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015875
 protein coding gene Chr10:119409035-119415081 (+)
CAST/EiJ MGP_CASTEiJ_G0017124
 protein coding gene Chr10:129880087-129887069 (+)
CBA/J MGP_CBAJ_G0017533
 protein coding gene Chr10:140459903-140467422 (+)
DBA/2J MGP_DBA2J_G0017639
 protein coding gene Chr10:124473032-124478628 (+)
FVB/NJ MGP_FVBNJ_G0017634
 protein coding gene Chr10:123424508-123429868 (+)
LP/J MGP_LPJ_G0017713
 protein coding gene Chr10:131186356-131194611 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017662
 protein coding gene Chr10:143199341-143205275 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018235
 protein coding gene Chr10:129153267-129159388 (+)
PWK/PhJ MGP_PWKPhJ_G0016909
 protein coding gene Chr10:124664139-124670291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016701
 protein coding gene Chr10:128180161-128184980 (+)
WSB/EiJ MGP_WSBEiJ_G0017185
 protein coding gene Chr10:129377918-129383143 (+)



Homology
more
  • Human Ortholog
    METTL1, methyltransferase 1, tRNA methylguanosine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL1, methyltransferase 1, tRNA methylguanosine
  • Synonyms
    C12orf1, TRM8, TRMT8, YDL201w
  • Links
    NCBI Gene ID: 4234
    neXtProt AC: NX_Q9UBP6
    UniProt: Q9UBP6

  • Chr Location
    12q14.1; chr12:57768471-57772119 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    39
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17299 NCBI Gene Model | MGI Sequence Detail 4948 C57BL/6J ±  kb
transcript NM_010792 RefSeq | MGI Sequence Detail 887 Not Specified  
polypeptide Q9Z120 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010341 tRNA (guanine-N(7)-)-methyltransferase
    (term hierarchy)
  • EC
    2.1.1.-, 2.1.1.33
  • InterPro Domains
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR025763 tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote
    IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 5
Other
Accession IDs
less
MGI:1917465
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:55326 Bahr A, et al., Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation. Genomics. 1999 May 1;57(3):424-8
  • Latest
    J:355649 Li Q, et al., Metabolic rewiring during bone development underlies tRNA m7G-associated primordial dwarfism. J Clin Invest. 2024 Sep 10;134(20)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory