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Scml2 Gene Detail
Summary
  • Symbol
    Scml2
  • Name
    Scm polycomb group protein like 2
  • Synonyms
    4932420G07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340042
    NCBI Gene: 107815
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:159865521-160041209 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 73.95 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340042
 protein coding gene ChrX:159865521-160041214 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036236
 protein coding gene ChrX:159022912-159214663 (+)
A/J MGP_AJ_G0036206
 protein coding gene ChrX:158314374-158461179 (+)
AKR/J MGP_AKRJ_G0036134
 protein coding gene ChrX:163348293-163504639 (+)
BALB/cJ MGP_BALBcJ_G0036199
 protein coding gene ChrX:156374778-156518066 (+)
C3H/HeJ MGP_C3HHeJ_G0035905
 protein coding gene ChrX:159458808-159601027 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036721
 protein coding gene ChrX:163758107-163949714 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033543
 protein coding gene ChrX:149492245-149646354 (+)
CAST/EiJ MGP_CASTEiJ_G0035194
 protein coding gene ChrX:138529291-138637229 (+)
CBA/J MGP_CBAJ_G0035880
 protein coding gene ChrX:168509795-168628468 (+)
DBA/2J MGP_DBA2J_G0036046
 protein coding gene ChrX:157257268-157398702 (+)
FVB/NJ MGP_FVBNJ_G0035977
 protein coding gene ChrX:156344351-156526897 (+)
LP/J MGP_LPJ_G0036131
 protein coding gene ChrX:160276617-160413502 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036009
 protein coding gene ChrX:177223139-177323156 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036762
 protein coding gene ChrX:158602941-158760179 (+)
PWK/PhJ MGP_PWKPhJ_G0034892
 protein coding gene ChrX:135347989-135458346 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034713
 protein coding gene ChrX:138925061-139035288 (+)
WSB/EiJ MGP_WSBEiJ_G0035329
 protein coding gene ChrX:156567894-156731731 (+)



Homology
more
  • Human Ortholog
    SCML2, Scm polycomb group protein like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCML2, Scm polycomb group protein like 2
  • Links
    NCBI Gene ID: 10389
    neXtProt AC: NX_Q9UQR0
    UniProt: Q9UQR0

  • Chr Location
    Xp22.13; chrX:18239313-18355118 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male sterility with small testis, impaired differentiation in spermatogenesis and apoptosis of differentiating male germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000037 Ensembl Gene Model | MGI Sequence Detail 175689 C57BL/6J ±  kb
    transcript ENSMUST00000077375 Ensembl | MGI Sequence Detail 3550 Not Applicable  
    polypeptide ENSMUSP00000076593 Ensembl | MGI Sequence Detail 969 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921621
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 19
    • Earliest
      J:46359 Blair HJ, et al., Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. Hum Mol Genet. 1998 Mar;7(3):549-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory