Adgrg1 Gene Detail

Summary

• Symbol
  Adgrg1
• Name
  adhesion G protein-coupled receptor G1
• Synonyms
  Cyt28, Gpr56

• Feature Type
  protein coding gene
• IDs
  MGI:1340051
  NCBI Gene: 14766
• Alliance
  gene page
• Transcription Start Sites
  35 TSS

Location &
Maps

• Sequence Map
  Chr8:95701379-95740845 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 47.12 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  1208 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1340051	protein coding gene	Chr8:95701321-95740845 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033976	protein coding gene	Chr8:96428448-96467037 (+)
A/J	MGP_AJ_G0033959	protein coding gene	Chr8:92666390-92704193 (+)
AKR/J	MGP_AKRJ_G0033885	protein coding gene	Chr8:95191859-95230680 (+)
BALB/cJ	MGP_BALBcJ_G0033951	protein coding gene	Chr8:92749697-92787742 (+)
C3H/HeJ	MGP_C3HHeJ_G0033661	protein coding gene	Chr8:95909482-95947904 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034472	protein coding gene	Chr8:99942472-99980171 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031413	protein coding gene	Chr8:86467998-86506003 (+)
CAST/EiJ	MGP_CASTEiJ_G0032993	protein coding gene	Chr8:95513299-95551659 (+)
CBA/J	MGP_CBAJ_G0033637	protein coding gene	Chr8:103245324-103288305 (+)
DBA/2J	MGP_DBA2J_G0033791	protein coding gene	Chr8:92154527-92192042 (+)
FVB/NJ	MGP_FVBNJ_G0033738	protein coding gene	Chr8:91097747-91135819 (+)
LP/J	MGP_LPJ_G0033883	protein coding gene	Chr8:96570252-96608819 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033780	protein coding gene	Chr8:105519857-105559198 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034490	protein coding gene	Chr8:95358894-95395882 (+)
PWK/PhJ	MGP_PWKPhJ_G0032695	protein coding gene	Chr8:91513740-91553145 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032532	protein coding gene	Chr8:94210425-94247563 (+)
WSB/EiJ	MGP_WSBEiJ_G0033105	protein coding gene	Chr8:95894558-95933520 (+)

Homology

• Human Ortholog
  ADGRG1, adhesion G protein-coupled receptor G1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ADGRG1, adhesion G protein-coupled receptor G1
  
• Synonyms
  BFPP, BPPR, CDCBM14B, CDCBM15A, GPR56, TM7LN4, TM7XN1
• Links
  HGNC:4512

  NCBI Gene ID: 9289

  neXtProt AC: NX_Q9Y653

  UniProt: Q9Y653

  
  
• Chr Location
  16q21; chr16:57610652-57665580 (+)  GRCh38

---

• MGI Vertebrate Homology
  Adgrg1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ADGRG1
• Gene Tree
  Adgrg1
  

Human Diseases

• Diseases
  2 with human ADGRG1 associations

				Human Disease	Mouse Models
				bilateral frontoparietal polymicrogyria IDs bilateral frontoparietal polymicrogyria       DOID:0080922 NCI:C148367 OMIM:606854
				bilateral perisylvian polymicrogyria IDs bilateral perisylvian polymicrogyria       DOID:0080924 OMIM:615752 ORDO:98889

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  23 phenotypes from 2 alleles in 3 genetic backgrounds
  27 phenotype references
  

• All Mutations and Alleles
  9
• Endonuclease-mediated
  4
• Gene trapped
  1
• Targeted
  4
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  33 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit defects in basement membranes of mutltiple tissues, resulting in neuronal ectopias in the frontoparietal cortex, male subfertility and testis defects, brain development, and hematopoietic stem cell development.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  41
• GO References
  12

Expression

• Assay Results
  1283
• Tissues
  131
• cDNA Data
  136
• Literature Summary
  21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase adgrg1
  ZFIN adgrg1

Sequences &
Gene Models

• All Sequences
  140
• RefSeq
  58
• UniProt
  11
• CCDS
  CCDS22553.1

• Ensembl
  ENSMUSG00000031785 (Evidence)
• NCBI Gene
  14766

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000031785	Ensembl Gene Model | MGI Sequence Detail	39467	C57BL/6J
transcript	ENSMUST00000093271	Ensembl | MGI Sequence Detail	3574	Not Applicable
polypeptide	ENSMUSP00000090959	Ensembl | MGI Sequence Detail	687	Not Applicable

Protein
Information

• UniProt
  11 Sequences
• Protein Ontology
  PR:000008189 adhesion G-protein coupled receptor G1
  (term hierarchy)
• PDB
  5KVM
• InterPro Domains
  IPR040950 ADGRG1, GAIN subdomain A
  IPR046338 GAIN domain superfamily
  IPR017981 GPCR, family 2-like, 7TM
  IPR003910 GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5
  IPR000832 GPCR, family 2, secretin-like
  IPR000203 GPS motif
  IPR040679 PTX/LNS-Like (PLL) domain
• GlyGen
  Q8K209 8 sites, 6 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 144

  Genomic 1

  cDNA 138

  Primer pair 3

  Other 2

  
  

  Microarray probesets 5

References

• Summaries
  All 74

  Developmental Gene Expression 21

  Gene Ontology 12

  Phenotypes 27
• Earliest
  J:53199 Liu M, et al., GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics. 1999 Feb 1;55(3):296-305
• Latest
  J:343406 Nojima Y, et al., GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons. Genes Cells. 2023 Feb;28(2):83-96

TSS for Adgrg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78926	Chr8:95700195-95700197 (+)	-1,183 bp
Tssr78927	Chr8:95701314-95701328 (+)	-58 bp
Tssr78928	Chr8:95701332-95701349 (+)	-38 bp
Tssr78929	Chr8:95703507-95703521 (+)	2,135 bp
Tssr78930	Chr8:95703729-95703751 (+)	2,361 bp
Tssr78931	Chr8:95703905-95703916 (+)	2,532 bp
Tssr78932	Chr8:95703924-95703937 (+)	2,552 bp
Tssr78933	Chr8:95703958-95703965 (+)	2,583 bp
Tssr78934	Chr8:95703980-95703996 (+)	2,609 bp
Tssr78935	Chr8:95704006-95704020 (+)	2,634 bp
Tssr2658	Chr8:95705525-95705534 (+)	4,151 bp
Tssr78936	Chr8:95708801-95708805 (+)	7,424 bp
Tssr2659	Chr8:95710657-95710669 (+)	9,284 bp
Tssr78937	Chr8:95710977-95710989 (+)	9,604 bp
Tssr78938	Chr8:95711037-95711105 (+)	9,692 bp
Tssr78939	Chr8:95712068-95712079 (+)	10,695 bp
Tssr78940	Chr8:95712151-95712196 (+)	10,795 bp
Tssr2660	Chr8:95712234-95712237 (+)	10,857 bp
Tssr78941	Chr8:95719311-95719330 (+)	17,942 bp
Tssr78942	Chr8:95719481-95719502 (+)	18,113 bp
Tssr78943	Chr8:95719548-95719565 (+)	18,178 bp
Tssr78944	Chr8:95720866-95720955 (+)	19,532 bp
Tssr78945	Chr8:95720993-95721018 (+)	19,627 bp
Tssr78946	Chr8:95721021-95721061 (+)	19,662 bp
Tssr78947	Chr8:95721321-95721349 (+)	19,956 bp
Tssr78948	Chr8:95721373-95721417 (+)	20,016 bp
Tssr78949	Chr8:95721421-95721431 (+)	20,047 bp
Tssr78950	Chr8:95721468-95721480 (+)	20,095 bp
Tssr78951	Chr8:95722219-95722249 (+)	20,855 bp
Tssr78952	Chr8:95722311-95722322 (+)	20,938 bp
Tssr78953	Chr8:95722332-95722376 (+)	20,975 bp
Tssr78954	Chr8:95722378-95722389 (+)	21,005 bp
Tssr78955	Chr8:95729037-95729079 (+)	27,679 bp
Tssr78956	Chr8:95729996-95730055 (+)	28,647 bp
Tssr78957	Chr8:95739914-95739941 (+)	38,549 bp