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Parp1 Gene Detail
Summary
  • Symbol
    Parp1
  • Name
    poly (ADP-ribose) polymerase family, member 1
  • Synonyms
    5830444G22Rik, Adprp, Adprt1, PARP, parp-1, sPARP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340806
    NCBI Gene: 11545
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180396456-180428564 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.44 cM, cytoband H5
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    984 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340806
 protein coding gene Chr1:180396456-180428819 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016870
 protein coding gene Chr1:187003678-187035955 (+)
A/J MGP_AJ_G0016849
 protein coding gene Chr1:179447179-179479946 (+)
AKR/J MGP_AKRJ_G0016815
 protein coding gene Chr1:184785497-184819751 (+)
BALB/cJ MGP_BALBcJ_G0016807
 protein coding gene Chr1:180072357-180108494 (+)
C3H/HeJ MGP_C3HHeJ_G0016632
 protein coding gene Chr1:185547543-185580167 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017270
 protein coding gene Chr1:193023717-193062584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014978
 protein coding gene Chr1:170437183-170469711 (+)
CAST/EiJ MGP_CASTEiJ_G0016213
 protein coding gene Chr1:184890529-184921655 (+)
CBA/J MGP_CBAJ_G0016606
 protein coding gene Chr1:200212850-200244879 (+)
DBA/2J MGP_DBA2J_G0016712
 protein coding gene Chr1:178289275-178322149 (+)
FVB/NJ MGP_FVBNJ_G0016708
 protein coding gene Chr1:176381401-176413670 (+)
LP/J MGP_LPJ_G0016786
 protein coding gene Chr1:188267946-188302205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016739
 protein coding gene Chr1:207388598-207422445 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017307
 protein coding gene Chr1:184558303-184593002 (+)
PWK/PhJ MGP_PWKPhJ_G0016001
 protein coding gene Chr1:177378684-177411311 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015777
 protein coding gene Chr1:183496851-183533400 (+)
WSB/EiJ MGP_WSBEiJ_G0016276
 protein coding gene Chr1:184762378-184796193 (+)



Homology
more
  • Human Ortholog
    PARP1, poly(ADP-ribose) polymerase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARP1, poly(ADP-ribose) polymerase 1
  • Synonyms
    ADPRT, ADPRT 1, ADPRT1, ARTD1, pADPRT-1, PARP, PARP-1, PARS, Poly-PARP, PPOL
  • Links
    NCBI Gene ID: 142
    neXtProt AC: NX_P09874
    UniProt: P09874

  • Chr Location
    1q42.12; chr1:226360210-226408154 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human PARP1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 6 alleles in 8 genetic backgrounds
    15 phenotypes from multigenic genotypes
    217 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous ablation of this gene may lead to skin hyperplasia, extreme sensitivity to radiation and alkylating agents, abnormal response to xenobiotics and endogenous compounds, reduced noise-induced hearing loss, altered susceptibility to neurotoxicity, or protection against renal ischemic injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    171
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    905
  • Tissues
    69
  • cDNA Data
    378
  • Literature Summary
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11545 NCBI Gene Model | MGI Sequence Detail 32109 C57BL/6J ±  kb
    transcript NM_007415 RefSeq | MGI Sequence Detail 3656 ZRU/MplStud  
    polypeptide P11103 UniProt | EBI | MGI Sequence Detail 1013 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 389
      Genomic 4
      cDNA 378
      Primer pair 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1132, MGI:2138374, MGI:2138692, MGI:87933
    References
    more
    • Summaries
      All 472
      Developmental Gene Expression 81
      Diseases 1
      Gene Ontology 39
      Phenotypes 217
    • Earliest
      J:9813 Huppi K, et al., Sequence and organization of the mouse poly (ADP-ribose) polymerase gene. Nucleic Acids Res. 1989 May 11;17(9):3387-401
    • Latest
      J:358182 Lin X, et al., Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts. Mol Cell. 2024 Oct 17;84(20):3916-3931.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory