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Adam2 Gene Detail
Summary
  • Symbol
    Adam2
  • Name
    a disintegrin and metallopeptidase domain 2
  • Synonyms
    fertilin beta, Ftnb, Ph30-beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340894
    NCBI Gene: 11495
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66264778-66315182 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.36 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1136 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340894
 protein coding gene Chr14:66264778-66315300 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021490
 protein coding gene Chr14:60671828-60728529 (-)
A/J MGP_AJ_G0021449
 protein coding gene Chr14:59252284-59304419 (-)
AKR/J MGP_AKRJ_G0021425
 protein coding gene Chr14:61310789-61365273 (-)
BALB/cJ MGP_BALBcJ_G0021455
 protein coding gene Chr14:59194811-59253724 (-)
C3H/HeJ MGP_C3HHeJ_G0021232
 protein coding gene Chr14:60989313-61043589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021894
 protein coding gene Chr14:63469912-63524554 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019434
 protein coding gene Chr14:57181519-57232536 (-)
CAST/EiJ MGP_CASTEiJ_G0020749
 protein coding gene Chr14:57468465-57520793 (-)
CBA/J MGP_CBAJ_G0021199
 protein coding gene Chr14:65395144-65460763 (-)
DBA/2J MGP_DBA2J_G0021322
 protein coding gene Chr14:58899081-58949803 (-)
FVB/NJ MGP_FVBNJ_G0021301
 protein coding gene Chr14:58310724-58361066 (-)
LP/J MGP_LPJ_G0021397
 protein coding gene Chr14:61720830-61775477 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021330
 protein coding gene Chr14:64467602-64527292 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021917
 protein coding gene Chr14:60504441-60558232 (-)
PWK/PhJ MGP_PWKPhJ_G0020493
 protein coding gene Chr14:55627771-55678789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020326
 protein coding gene Chr14:56474974-56527676 (-)
WSB/EiJ MGP_WSBEiJ_G0020802
 protein coding gene Chr14:60804343-60863029 (-)



Homology
more
  • Human Ortholog
    ADAM2, ADAM metallopeptidase domain 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM2, ADAM metallopeptidase domain 2
  • Synonyms
    CRYN1, CRYN2, CT15, FTNB, PH30, PH-30b, PH30-beta
  • Links
    NCBI Gene ID: 2515
    neXtProt AC: NX_Q99965
    UniProt: Q99965

  • Chr Location
    8p11.22; chr8:39743735-39838227 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are viable, females are fertile, but males have severely reduced fertility. Mutant male sperm are defective in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus to theoviduct, and binding to the egg zona pellucida.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    45
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022039 Ensembl Gene Model | MGI Sequence Detail 50405 C57BL/6J ±  kb
    transcript ENSMUST00000022618 Ensembl | MGI Sequence Detail 2551 Not Applicable  
    polypeptide ENSMUSP00000022618 Ensembl | MGI Sequence Detail 735 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 14
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27045, MGI:104682, MGI:2145619
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:25265 Wolfsberg TG, et al., ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev Biol. 1995 May;169(1):378-83
    • Latest
      J:256987 Shi B, et al., MORC2B is essential for meiotic progression and fertility. PLoS Genet. 2018 Jan;14(1):e1007175
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory