Ccni MGI Mouse Gene Detail - MGI:1341077

Symbol

Ccni
Name

cyclin I

Feature Type

protein coding gene
IDs

MGI:1341077
NCBI Gene: 12453
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:93329796-93354348 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 47.29 cM, cytoband E3.3-F1.3
Mapping Data

2 experiments

SNPs within 2kb

614 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341077	protein coding gene	Chr5:93329792-93354354 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029759	protein coding gene	Chr5:94403341-94428823 (-)
A/J	MGP_AJ_G0029725	protein coding gene	Chr5:90653314-90677136 (-)
AKR/J	MGP_AKRJ_G0029671	protein coding gene	Chr5:93636425-93672539 (-)
BALB/cJ	MGP_BALBcJ_G0029735	protein coding gene	Chr5:91526351-91550793 (-)
C3H/HeJ	MGP_C3HHeJ_G0029458	protein coding gene	Chr5:94018928-94050554 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030189	protein coding gene	Chr5:98143686-98170626 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027425	protein coding gene	Chr5:86272636-86297111 (-)
CAST/EiJ	MGP_CASTEiJ_G0028868	protein coding gene	Chr5:93405898-93432910 (-)
CBA/J	MGP_CBAJ_G0029428	protein coding gene	Chr5:101559469-101588318 (-)
DBA/2J	MGP_DBA2J_G0029572	protein coding gene	Chr5:90698045-90720748 (-)
FVB/NJ	MGP_FVBNJ_G0029531	protein coding gene	Chr5:89556536-89580714 (-)
LP/J	MGP_LPJ_G0029660	protein coding gene	Chr5:94768606-94793197 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029560	protein coding gene	Chr5:106437274-106469041 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030223	protein coding gene	Chr5:93149559-93174130 (-)
PWK/PhJ	MGP_PWKPhJ_G0028587	protein coding gene	Chr5:89762928-89788831 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028422	protein coding gene	Chr5:92486620-92511869 (-)
WSB/EiJ	MGP_WSBEiJ_G0028947	protein coding gene	Chr5:93618741-93642561 (-)

Human Ortholog

CCNI, cyclin I

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCNI, cyclin I
Synonyms

CCNI1, CYC1, CYI
Links

HGNC:1595

NCBI Gene ID: 10983

neXtProt AC: NX_Q14094

UniProt: Q14094
Chr Location

4q21.1; chr4:77047155-77076309 (-) GRCh38

MGI Vertebrate Homology

Ccni stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCNI
Gene Tree

Ccni

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

3 involving Ccni
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation are viable and fertile and do not display any gross physical or behavioral abnormalities.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

8
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCNI

Xenbase ccni

ZFIN ccni

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All Sequences

92
RefSeq

6
UniProt

6
CCDS

CCDS19436.1

Ensembl

ENSMUSG00000063015 (Evidence)
NCBI Gene

12453

			Length	Strain/Species	Flank
genomic	12453	NCBI Gene Model \| MGI Sequence Detail	24553	C57BL/6J	± kb
transcript	NM_001420723	RefSeq \| MGI Sequence Detail	2858	C57BL/6
polypeptide	Q9Z2V9	UniProt \| EBI \| MGI Sequence Detail	377	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005131 cyclin-I

(term hierarchy)
InterPro Domains

IPR039361 Cyclin

IPR013763 Cyclin-like domain

IPR036915 Cyclin-like superfamily

IPR006671 Cyclin, N-terminal

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All nucleic 19

Genomic 1

cDNA 17

Primer pair 1

Microarray probesets 12

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:223852 Hagmann H, et al., Cyclin I and p35 determine the subcellular distribution of Cdk5. Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C339-47

TSS for Ccni:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51942	Chr5:93354348-93354357 (-)	-5 bp
Tssr51941	Chr5:93354301-93354329 (-)	33 bp
Tssr51940	Chr5:93353573-93353577 (-)	773 bp
Tssr51939	Chr5:93353223-93353235 (-)	1,119 bp
Tssr51938	Chr5:93340801-93340805 (-)	13,545 bp
Tssr51937	Chr5:93338136-93338144 (-)	16,208 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24