Adcy8 MGI Mouse Gene Detail - MGI:1341110

Symbol

Adcy8
Name

adenylate cyclase 8
Synonyms

AC8

Feature Type

protein coding gene
IDs

MGI:1341110
NCBI Gene: 11514
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:64570884-64794145 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 29.03 cM
Mapping Data

3 experiments

SNPs within 2kb

7401 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341110	protein coding gene	Chr15:64568933-64794145 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021897	protein coding gene	Chr15:64176517-64417723 (-)
A/J	MGP_AJ_G0021856	protein coding gene	Chr15:61713651-61950937 (-)
AKR/J	MGP_AKRJ_G0021838	protein coding gene	Chr15:63432682-63685050 (-)
BALB/cJ	MGP_BALBcJ_G0021863	protein coding gene	Chr15:61914370-62145331 (-)
C3H/HeJ	MGP_C3HHeJ_G0021637	protein coding gene	Chr15:63567965-63795107 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022302	protein coding gene	Chr15:66666873-66902567 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019841	protein coding gene	Chr15:58589806-58808950 (-)
CAST/EiJ	MGP_CASTEiJ_G0021155	protein coding gene	Chr15:64248304-64479502 (-)
CBA/J	MGP_CBAJ_G0021603	protein coding gene	Chr15:68922079-69177919 (-)
DBA/2J	MGP_DBA2J_G0021727	protein coding gene	Chr15:61542586-61764332 (-)
FVB/NJ	MGP_FVBNJ_G0021709	protein coding gene	Chr15:60577036-60791466 (-)
LP/J	MGP_LPJ_G0021799	protein coding gene	Chr15:64047130-64292050 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021732	protein coding gene	Chr15:73920915-74178790 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022324	protein coding gene	Chr15:63838565-64074929 (-)
PWK/PhJ	MGP_PWKPhJ_G0020897	protein coding gene	Chr15:61636278-61856700 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020738	protein coding gene	Chr15:63653316-63915016 (-)
WSB/EiJ	MGP_WSBEiJ_G0021207	protein coding gene	Chr15:63805508-64037995 (-)

Human Ortholog

ADCY8, adenylate cyclase 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADCY8, adenylate cyclase 8
Synonyms

AC8, ADCY3, HBAC1
Links

HGNC:239

NCBI Gene ID: 114

neXtProt AC: NX_P40145

UniProt: P40145
Chr Location

8q24.22; chr8:130780301-131040909 (-) GRCh38

MGI Vertebrate Homology

Adcy8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADCY8
Protein SuperFamily

Ade_cyc
Gene Tree

Adcy8

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References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
71 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

3
Endonuclease-mediated

5
Radiation induced

2
Targeted

2
Genomic Mutations

5 involving Adcy8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in reduced body size (in female animals only), reduced anxiety, and impaired long term depression (LTD).

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All GO Annotations

105
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1147
Tissues

204
cDNA Data

34
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adcy8

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS27506.1, CCDS88771.1

Ensembl

ENSMUSG00000022376 (Evidence)
NCBI Gene

11514

			Length	Strain/Species	Flank
genomic	11514	NCBI Gene Model \| MGI Sequence Detail	223262	C57BL/6J	± kb
transcript	NM_009623	RefSeq \| MGI Sequence Detail	5064	ZRU/MplStud
polypeptide	P97490	UniProt \| EBI \| MGI Sequence Detail	1249	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003759 adenylate cyclase type 8

(term hierarchy)
EC

4.6.1.1
InterPro Domains

IPR030672 Adenylate cyclase

IPR009398 Adenylate cyclase, conserved domain

IPR032628 Adenylate cyclase, N-terminal

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site

IPR029787 Nucleotide cyclase
GlyGen

P97490 4 sites, 1 N-linked glycan (1 site)

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All nucleic 37

Genomic 1

cDNA 34

Primer pair 2

Microarray probesets 3

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MGI:2146186

Summaries

All 117

Developmental Gene Expression 13

Diseases 1

Gene Ontology 20

Phenotypes 71
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:343823 Zhang M, et al., Ca(2+)-stimulated ADCY1 and ADCY8 regulate distinct aspects of synaptic and cognitive flexibility. Front Cell Neurosci. 2023;17:1215255

TSS for Adcy8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134551	Chr15:64794984-64795011 (-)	-853 bp
Tssr134550	Chr15:64794174-64794190 (-)	-37 bp
Tssr134549	Chr15:64794139-64794164 (-)	-7 bp
Tssr134548	Chr15:64793459-64793537 (-)	647 bp
Tssr4612	Chr15:64793306-64793334 (-)	825 bp
Tssr134547	Chr15:64793234-64793252 (-)	902 bp
Tssr134546	Chr15:64792833-64792844 (-)	1,306 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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