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Gldc Gene Detail
Summary
  • Symbol
    Gldc
  • Name
    glycine decarboxylase
  • Synonyms
    b2b2679Clo, D030049L12Rik, D19Wsu57e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341155
    NCBI Gene: 104174
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:30075847-30152829 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 24.87 cM, cytoband C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2858 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341155
 protein coding gene Chr19:30075847-30152829 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025032
 protein coding gene Chr19:28591039-28674216 (-)
A/J MGP_AJ_G0025009
 protein coding gene Chr19:27173359-27251930 (-)
AKR/J MGP_AKRJ_G0024977
 protein coding gene Chr19:28136286-28214908 (-)
BALB/cJ MGP_BALBcJ_G0025008
 protein coding gene Chr19:27209441-27286893 (-)
C3H/HeJ MGP_C3HHeJ_G0024764
 protein coding gene Chr19:28102302-28183458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025449
 protein coding gene Chr19:29370085-29453194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022868
 protein coding gene Chr19:27146677-27229312 (-)
CAST/EiJ MGP_CASTEiJ_G0024234
 protein coding gene Chr19:27970419-28052226 (-)
CBA/J MGP_CBAJ_G0024742
 protein coding gene Chr19:30771835-30851503 (-)
DBA/2J MGP_DBA2J_G0024874
 protein coding gene Chr19:27112340-27195074 (-)
FVB/NJ MGP_FVBNJ_G0024836
 protein coding gene Chr19:26950381-27027393 (-)
LP/J MGP_LPJ_G0024959
 protein coding gene Chr19:28590047-28675121 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024863
 protein coding gene Chr19:30661125-30741948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025504
 protein coding gene Chr19:28153115-28234462 (-)
PWK/PhJ MGP_PWKPhJ_G0023982
 protein coding gene Chr19:26781354-26859946 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023786
 protein coding gene Chr19:27472420-27555742 (-)
WSB/EiJ MGP_WSBEiJ_G0024301
 protein coding gene Chr19:28201810-28279847 (-)



Homology
more
  • Human Ortholog
    GLDC, glycine decarboxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLDC, glycine decarboxylase
  • Synonyms
    GCE, GCE1, GCSP, HYGN1
  • Links
    NCBI Gene ID: 2731
    neXtProt AC: NX_P23378
    UniProt: P23378

  • Chr Location
    9p24.1; chr9:6532467-6645729 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gldc mouse models; 1 with human GLDC associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hypomorphic mutants show a developmental delay, hyperglycinemia, altered folate profiles, neural tube defects and postnatal lethality, while survivors show hydrocephaly and premature death. Homozygotes for an ENU allele show omphalocele and severe cardiovascular, craniofacial, renal and eye defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    149
  • cDNA Data
    96
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104174 NCBI Gene Model | MGI Sequence Detail 76983 C57BL/6J ±  kb
    transcript NM_138595 RefSeq | MGI Sequence Detail 3767 ZRU/MplStud  
    polypeptide Q91W43 UniProt | EBI | MGI Sequence Detail 1025 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008022 glycine dehydrogenase (decarboxylating), mitochondrial
      (term hierarchy)
    • EC
      1.4.4.2
    • InterPro Domains
      IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
      IPR020581 Glycine cleavage system P protein
      IPR049315 Glycine cleavage system P-protein, N-terminal domain
      IPR049316 Glycine dehydrogenase, C-terminal domain
      IPR003437 Glycine dehydrogenase (decarboxylating)
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      Q91W43 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 104
      Genomic 2
      cDNA 97
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33938, MGI:106246, MGI:2441935, MGI:5560791
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory