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Fcnb Gene Detail
Summary
  • Symbol
    Fcnb
  • Name
    ficolin B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341158
    NCBI Gene: 14134
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27966491-27974921 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    342 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341158
 protein coding gene Chr2:27966390-27974921 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025518
 protein coding gene Chr2:26089863-26098370 (-)
A/J MGP_AJ_G0025495
 protein coding gene Chr2:25124448-25132955 (-)
AKR/J MGP_AKRJ_G0025465
 protein coding gene Chr2:25955331-25963838 (-)
BALB/cJ MGP_BALBcJ_G0025491
 protein coding gene Chr2:25243653-25252160 (-)
C3H/HeJ MGP_C3HHeJ_G0025252
 protein coding gene Chr2:25863075-25871582 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025935
 protein coding gene Chr2:26988203-26996710 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023346
 protein coding gene Chr2:23931658-23940173 (-)
CAST/EiJ MGP_CASTEiJ_G0024715
 protein coding gene Chr2:25771441-25779938 (-)
CBA/J MGP_CBAJ_G0025230
 protein coding gene Chr2:27911404-27919911 (-)
DBA/2J MGP_DBA2J_G0025363
 protein coding gene Chr2:24936067-24944574 (-)
FVB/NJ MGP_FVBNJ_G0025325
 protein coding gene Chr2:24710456-24718963 (-)
LP/J MGP_LPJ_G0025449
 protein coding gene Chr2:26049183-26057690 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025356
 protein coding gene Chr2:27919474-27927976 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025994
 protein coding gene Chr2:25858317-25866824 (-)
PWK/PhJ MGP_PWKPhJ_G0024463
 protein coding gene Chr2:24734130-24742627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024263
 protein coding gene Chr2:26024167-26032680 (-)
WSB/EiJ MGP_WSBEiJ_G0024784
 protein coding gene Chr2:25999053-26007560 (-)



Homology
more
  • Human Ortholog
    FCN1, ficolin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCN1, ficolin 1
  • Synonyms
    FCNM
  • Links
    NCBI Gene ID: 2219
    neXtProt AC: NX_O00602
    UniProt: O00602

  • Chr Location
    9q34.3; chr9:134903232-134917912 (-)  GRCh38
  • Human Ortholog
    FCN2, ficolin 2
  • Synonyms
    EBP-37, FCNL, ficolin-2, P35
  • Links
    NCBI Gene ID: 2220
    neXtProt AC: NX_Q15485
    UniProt: Q15485

  • Chr Location
    9q34.3; chr9:134864144-134887523 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to Streptococcus pneumoniae infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    27
  • cDNA Data
    8
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14134 NCBI Gene Model | MGI Sequence Detail 8431 C57BL/6J ±  kb
transcript NM_010190 RefSeq | MGI Sequence Detail 1062 Not Specified  
polypeptide O70497 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR008160 Collagen triple helix repeat
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR020837 Fibrinogen, conserved site
    IPR050373 Fibrinogen C-terminal domain-containing protein
    IPR036056 Fibrinogen-like, C-terminal
  • GlyGen
    O70497 1 site
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 8
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:48250 Iwama A, et al., Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15;26(12):3034-43
  • Latest
    J:292131 Jarlhelt I, et al., The ficolin response to LPS challenge in mice. Mol Immunol. 2019 Apr;108:121-127
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory