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Cnmd Gene Detail
Summary
  • Symbol
    Cnmd
  • Name
    chondromodulin
  • Synonyms
    Bricd3, Chmd, ChM-I, Chondromodulin 1, Lect1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341171
    NCBI Gene: 16840
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:79875126-79899596 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 42.74 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341171
 protein coding gene Chr14:79875126-79899610 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021602
 protein coding gene Chr14:74784179-74808781 (-)
A/J MGP_AJ_G0021560
 protein coding gene Chr14:72918511-72942920 (-)
AKR/J MGP_AKRJ_G0021536
 protein coding gene Chr14:75086964-75112418 (-)
BALB/cJ MGP_BALBcJ_G0021566
 protein coding gene Chr14:72767799-72792234 (-)
C3H/HeJ MGP_C3HHeJ_G0021344
 protein coding gene Chr14:74817461-74841936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022006
 protein coding gene Chr14:77946259-77972104 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019545
 protein coding gene Chr14:70444751-70471515 (-)
CAST/EiJ MGP_CASTEiJ_G0020859
 protein coding gene Chr14:71602411-71629589 (-)
CBA/J MGP_CBAJ_G0021312
 protein coding gene Chr14:80454746-80479193 (-)
DBA/2J MGP_DBA2J_G0021436
 protein coding gene Chr14:72318553-72342983 (-)
FVB/NJ MGP_FVBNJ_G0021412
 protein coding gene Chr14:71655889-71680347 (-)
LP/J MGP_LPJ_G0021504
 protein coding gene Chr14:75874246-75898734 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021440
 protein coding gene Chr14:79116783-79141975 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022029
 protein coding gene Chr14:74401741-74426206 (-)
PWK/PhJ MGP_PWKPhJ_G0020604
 protein coding gene Chr14:69111425-69136475 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020440
 protein coding gene Chr14:70370377-70396232 (-)
WSB/EiJ MGP_WSBEiJ_G0020914
 protein coding gene Chr14:74759419-74783798 (-)



Homology
more
  • Human Ortholog
    CNMD, chondromodulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNMD, chondromodulin
  • Synonyms
    BRICD3, CHM1, CHM-I, LECT1, MYETS1
  • Links
    NCBI Gene ID: 11061
    neXtProt AC: NX_O75829
    UniProt: O75829

  • Chr Location
    13q14.3; chr13:52703264-52739820 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and show no gross morphologic defects. While cartilage development and embryonic endochondral bone formation were found to be normal in mutant mice, one line of targeted mutants showed increased bone density and impairedbone resorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1014
  • Tissues
    120
  • cDNA Data
    30
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16840 NCBI Gene Model | MGI Sequence Detail 24471 C57BL/6J ±  kb
    transcript NM_001310655 RefSeq | MGI Sequence Detail 1438 C57BL/6  
    polypeptide Q9Z1F6 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 31
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 33
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:54632 Hiraki Y, et al., Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes. Biochem Biophys Res Commun. 1991 Mar 29;175(3):971-7
    • Latest
      J:332093 Szeto IYY, et al., SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2122121119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory