Tpbg MGI Mouse Gene Detail - MGI:1341264 - trophoblast glycoprotein

Symbol

Tpbg
Name

trophoblast glycoprotein
Synonyms

5T4, 5T4 oncofetal antigen

Feature Type

protein coding gene
IDs

MGI:1341264
NCBI Gene: 21983
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:85724433-85729093 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 46.40 cM
Mapping Data

2 experiments

SNPs within 2kb

197 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341264	protein coding gene	Chr9:85724433-85729110 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035093	protein coding gene	Chr9:86639278-86643746 (+)
A/J	MGP_AJ_G0035074	protein coding gene	Chr9:83615264-83620487 (+)
AKR/J	MGP_AKRJ_G0035002	protein coding gene	Chr9:85603001-85607697 (+)
BALB/cJ	MGP_BALBcJ_G0035062	protein coding gene	Chr9:83264001-83268651 (+)
C3H/HeJ	MGP_C3HHeJ_G0034774	protein coding gene	Chr9:86081204-86085841 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035586	protein coding gene	Chr9:88989022-88993672 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032493	protein coding gene	Chr9:82433292-82437987 (+)
CAST/EiJ	MGP_CASTEiJ_G0034092	protein coding gene	Chr9:86553180-86558786 (+)
CBA/J	MGP_CBAJ_G0034747	protein coding gene	Chr9:92186883-92191593 (+)
DBA/2J	MGP_DBA2J_G0034905	protein coding gene	Chr9:83186978-83191632 (+)
FVB/NJ	MGP_FVBNJ_G0034848	protein coding gene	Chr9:82310005-82314580 (+)
LP/J	MGP_LPJ_G0034986	protein coding gene	Chr9:86846961-86851650 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034890	protein coding gene	Chr9:93741667-93746148 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035606	protein coding gene	Chr9:85724822-85730475 (+)
PWK/PhJ	MGP_PWKPhJ_G0033796	protein coding gene	Chr9:83375182-83379954 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033632	protein coding gene	Chr9:85933618-85938303 (+)
WSB/EiJ	MGP_WSBEiJ_G0034209	protein coding gene	Chr9:85759071-85763731 (+)

Human Ortholog

TPBG, trophoblast glycoprotein

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPBG, trophoblast glycoprotein
Synonyms

5T4, 5T4AG, M6P1, WAIF1
Links

HGNC:12004

NCBI Gene ID: 7162

neXtProt AC: NX_Q13641

UniProt: Q13641
Chr Location

6q14.1; chr6:82362983-82367420 (+) GRCh38

MGI Vertebrate Homology

Tpbg stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: TPBG
Gene Tree

Tpbg

less

Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Tpbg
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a knock-out allele exhibit low penetrance hydrocephaly and premature death. Embryonic stem cells isolated from these mice exhibit impaired mesenchyme differentiation and reduced chemotaxis following differentiation.

less

All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

872
Tissues

77
cDNA Data

11
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tpbg

ZFIN tpbg

less

All Sequences

49
RefSeq

10
UniProt

2
CCDS

CCDS23380.1

Ensembl

ENSMUSG00000035274 (Evidence)
NCBI Gene

21983

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035274	Ensembl Gene Model \| MGI Sequence Detail	4661	C57BL/6J	± kb
transcript	ENSMUST00000006559	Ensembl \| MGI Sequence Detail	3603	Not Applicable
polypeptide	ENSMUSP00000006559	Ensembl \| MGI Sequence Detail	426	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000016569 trophoblast glycoprotein

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

IPR052286 Wnt/beta-catenin signaling inhibitor
GlyGen

Q9Z0L0 6 sites, 12 N-linked glycans (6 sites)

less

All nucleic 12

cDNA 12

Microarray probesets 2

less

MGI:2143309

Summaries

All 45

Developmental Gene Expression 9

Gene Ontology 9

Phenotypes 18
Earliest

J:55628 King KW, et al., Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. Biochim Biophys Acta. 1999 Jun 9;1445(3):257-70
Latest

J:343680 Wakeham CM, et al., Trophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells. Front Cell Neurosci. 2023;17:1306006

TSS for Tpbg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86383	Chr9:85724584-85724595 (+)	157 bp
Tssr2955	Chr9:85724762-85724774 (+)	335 bp
Tssr86384	Chr9:85724777-85724814 (+)	363 bp
Tssr86385	Chr9:85724915-85724933 (+)	491 bp
Tssr86386	Chr9:85724936-85724955 (+)	513 bp
Tssr86387	Chr9:85725425-85725439 (+)	999 bp
Tssr86388	Chr9:85727371-85727374 (+)	2,940 bp
Tssr86389	Chr9:85727554-85727558 (+)	3,123 bp
Tssr86390	Chr9:85727651-85727654 (+)	3,220 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24