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Ggps1 Gene Detail
Summary
  • Symbol
    Ggps1
  • Name
    geranylgeranyl diphosphate synthase 1
  • Synonyms
    1810026C22Rik, 9530089B04Rik, GGPPS, GGPP synthase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341724
    NCBI Gene: 14593
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:14225244-14238073 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 5.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    302 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341724
 protein coding gene Chr13:14224375-14238319 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020241
 protein coding gene Chr13:11020778-11032541 (-)
A/J MGP_AJ_G0020199
 protein coding gene Chr13:10945459-10956305 (-)
AKR/J MGP_AKRJ_G0020173
 protein coding gene Chr13:11064016-11075012 (-)
BALB/cJ MGP_BALBcJ_G0020185
 protein coding gene Chr13:10926876-10937829 (-)
C3H/HeJ MGP_C3HHeJ_G0019989
 protein coding gene Chr13:11224791-11235743 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020629
 protein coding gene Chr13:11595007-11606020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018235
 protein coding gene Chr13:9675285-9687550 (-)
CAST/EiJ MGP_CASTEiJ_G0020282
 protein coding gene Chr14:12090161-12092602 (-)
CBA/J MGP_CBAJ_G0019953
 protein coding gene Chr13:11953717-11964640 (-)
DBA/2J MGP_DBA2J_G0020072
 protein coding gene Chr13:10595162-10606477 (-)
FVB/NJ MGP_FVBNJ_G0020053
 protein coding gene Chr13:10355138-10366089 (-)
LP/J MGP_LPJ_G0020142
 protein coding gene Chr13:11205296-11217912 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020090
 protein coding gene Chr13:12051314-12065247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020656
 protein coding gene Chr13:10867914-10878846 (-)
PWK/PhJ MGP_PWKPhJ_G0019286
 protein coding gene Chr13:10670324-10676315 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019093
 protein coding gene Chr13:10033270-10045861 (-)
WSB/EiJ MGP_WSBEiJ_G0019584
 protein coding gene Chr13:10889959-10901109 (-)



Homology
more
  • Human Ortholog
    GGPS1, geranylgeranyl diphosphate synthase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GGPS1, geranylgeranyl diphosphate synthase 1
  • Synonyms
    GGPPS, GGPPS1, MDHLO, MUDHLOV
  • Links
    NCBI Gene ID: 9453
    neXtProt AC: NX_O95749
    UniProt: O95749

  • Chr Location
    1q42.3; chr1:235327216-235344532 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    33
  • cDNA Data
    25
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021302 Ensembl Gene Model | MGI Sequence Detail 12830 C57BL/6J ±  kb
    transcript ENSMUST00000170957 Ensembl | MGI Sequence Detail 4244 Not Applicable  
    polypeptide ENSMUSP00000126603 Ensembl | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 6
      cDNA 25
      Primer pair 5

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1916424, MGI:1925988, MGI:2145293, MGI:2145506
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 37
    • Earliest
      J:54347 Kainou T, et al., Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. Biochim Biophys Acta. 1999 Mar 25;1437(3):333-40
    • Latest
      J:358837 Shao X, et al., Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease. FASEB J. 2024 Sep 15;38(17):e23875
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory