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Hey1 Gene Detail
Summary
  • Symbol
    Hey1
  • Name
    hairy/enhancer-of-split related with YRPW motif 1
  • Synonyms
    bHLHb31, CHF2, Herp2, hesr-1, Hesr1, HRT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341800
    NCBI Gene: 15213
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr3:8728419-8732098 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 2.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341800
 protein coding gene Chr3:8728419-8732316 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027053
 protein coding gene Chr3:5499121-5503018 (-)
A/J MGP_AJ_G0027017
 protein coding gene Chr3:5751528-5755425 (-)
AKR/J MGP_AKRJ_G0026987
 protein coding gene Chr3:5634848-5638742 (-)
BALB/cJ MGP_BALBcJ_G0027026
 protein coding gene Chr3:5468432-5472328 (-)
C3H/HeJ MGP_C3HHeJ_G0026766
 protein coding gene Chr3:5882414-5888416 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027470
 protein coding gene Chr3:6096585-6100482 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024832
 protein coding gene Chr3:4737683-4741566 (-)
CAST/EiJ MGP_CASTEiJ_G0026224
 protein coding gene Chr3:5901689-5905585 (-)
CBA/J MGP_CBAJ_G0026744
 protein coding gene Chr3:5997604-6001501 (-)
DBA/2J MGP_DBA2J_G0026880
 protein coding gene Chr3:5343001-5346895 (-)
FVB/NJ MGP_FVBNJ_G0026847
 protein coding gene Chr3:5229159-5233053 (-)
LP/J MGP_LPJ_G0026990
 protein coding gene Chr3:6019200-6023097 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026867
 protein coding gene Chr3:7142462-7146349 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027530
 protein coding gene Chr3:5457722-5461616 (-)
PWK/PhJ MGP_PWKPhJ_G0025959
 protein coding gene Chr3:5539748-5543841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025762
 protein coding gene Chr3:5555281-5598287 (-)
WSB/EiJ MGP_WSBEiJ_G0026295
 protein coding gene Chr3:5467919-5471815 (-)



Homology
more
  • Human Ortholog
    HEY1, hes related family bHLH transcription factor with YRPW motif 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HEY1, hes related family bHLH transcription factor with YRPW motif 1
  • Synonyms
    BHLHb31, CHF2, HERP2, HESR1, hHRT1, HRT-1, NERP2, OAF1
  • Links
    NCBI Gene ID: 23462
    neXtProt AC: NX_Q9Y5J3
    UniProt: Q9Y5J3

  • Chr Location
    8q21.13; chr8:79762371-79767857 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 3 genetic backgrounds
    54 phenotypes from multigenic genotypes
    24 phenotype references
Homozygous null mice are healthy and fertile with no major developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1258
  • Tissues
    310
  • cDNA Data
    121
  • Literature Summary
    247
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15213 NCBI Gene Model | MGI Sequence Detail 3680 C57BL/6J ±  kb
transcript NM_010423 RefSeq | MGI Sequence Detail 2215 ZRU/MplStud  
polypeptide Q9WV93 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008528 hairy/enhancer-of-split related with YRPW motif protein 1
    (term hierarchy)
  • InterPro Domains
    IPR050370 Hairy and Enhancer of Split/HEY-related
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
less
  • All nucleic 151
    cDNA 122
    Primer pair 17
    Other 12

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139670, MGI:2139691
References
more
  • Summaries
    All 304
    Developmental Gene Expression 247
    Gene Ontology 25
    Phenotypes 24
  • Earliest
    J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
  • Latest
    J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory